Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	34624
Country	Italy

Received	2017-05-11 08:40
Peer-Review Started	2017-05-11 16:31
To Make the First Decision	2017-05-23 00:48
Return for Revision	2017-05-23 09:48
Revised	2017-05-24 15:21
Second Decision	2017-06-22 02:16
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-07-03 02:42
Articles in Press	2017-07-03 02:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-08-31 09:05
Publish the Manuscript Online	2017-09-11 01:10

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Polyethylene glycol microspheres loaded with irinotecan for arterially directed embolic therapy of metastatic liver cancer
Manuscript Source	Invited Manuscript
All Author List	Giammaria Fiorentini, Riccardo Carandina, Donatella Sarti, Michele Nardella, Odysseas Zoras, Stefano Guadagni, Riccardo Inchingolo, Massimiliano Nestola, Alessandro Felicioli, Daniel Barnes Navarro, Fernando Munos Gomez and Camillo Aliberti
ORCID	Author(s) ORCID Number Giammaria Fiorentini http://orcid.org/0000-0002-5615-889X Riccardo Carandina http://orcid.org/0000-0002-5034-9863 Donatella Sarti http://orcid.org/0000-0002-8031-7846 Michele Nardella http://orcid.org/0000-0002-1573-511X Odysseas Zoras http://orcid.org/0000-0001-8805-2494 Stefano Guadagni http://orcid.org/0000-0001-8525-084X Riccardo Inchingolo http://orcid.org/0000-0002-0253-5936 Massimiliano Nestola http://orcid.org/0000-0001-9611-865X Alessandro Felicioli http://orcid.org/0000-0003-3052-8503 Daniel Barnes Navarro http://orcid.org/0000-0002-3781-7570 Fernando Munos Gomez http://orcid.org/ 0000-0003-0944-9819 Camillo Aliberti http://orcid.org/ 0000-0002-0941-7457
Funding Agency and Grant Number
Corresponding Author	Dr. Giammaria Fiorentini, Onco-Ematology Department, Azienda Ospedaliera “Ospedali Riuniti Marche Nord”, Via Lombroso 1, 61122 Pesaro, Italy. g.fiorentini@alice.it
Key Words	Liver metastases; Arterially directed embolic therapy; Colorectal cancer; Polyethylene glycol embolics; Irinotecan
Core Tip	Patients with liver metastases from colorectal cancer are in 80% of cases non-indicated for resection. The standard first line treatment of unresectable liver metastases is systemic chemotherapy, however this method results in progression for 70% of patients. The indicated therapy for refractory patients is the chemoembolization. In this study, we monitored tumor response, and adverse events after chemoembolization of colorectal cancer liver metastases with polyethylene glycol embolics loaded with irinotecan. Chemoembolization with these embolics is effective in terms of tumor response, time to progression, survival and quality of life and resulted in mild toxicity.
Publish Date	2017-09-11 01:10
Citation	Fiorentini G, Carandina R, Sarti D, Nardella M, Zoras O, Guadagni S, Inchingolo R, Nestola M, Felicioli A, Barnes Navarro D, Munoz Gomez F, Aliberti C. Polyethylene glycol microspheres loaded with irinotecan for arterially directed embolic therapy of metastatic liver cancer. World J Gastrointest Oncol 2017; 9(9): 379-384
URL	http://www.wjgnet.com/1948-5204/full/v9/i9/379.htm
DOI	http://dx.doi.org/10.4251/wjgo.v9.i9.379

Full Article (PDF)	WJGO-9-379.pdf
Full Article (Word)	WJGO-9-379.doc
Manuscript File	34624-Review.doc
Answering Reviewers	34624-Answering reviewers.pdf
Audio Core Tip	34624-Audio core tip.mp3
Clinical Trial Registration Statement	34624-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	34624-Conflict-of-interest statement.pdf
Copyright License Agreement	34624-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	34624-Institutional review board statement.pdf
Peer-review Report	34624-Peer-review(s).pdf
Scientific Misconduct Check	34624-Scientific misconduct check.pdf
Scientific Editor Work List	34624-Scientific editor work list.pdf