BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
10/29/2017 6:01:43 AM | Browse: 1000 | Download: 1273
Publication Name World Journal of Gastroenterology
Manuscript ID 34639
Country/Territory China
Received
2017-05-12 08:32
Peer-Review Started
2017-05-13 16:44
To Make the First Decision
2017-06-22 05:59
Return for Revision
2017-06-27 09:22
Revised
2017-07-24 09:16
Second Decision
2017-08-21 04:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-08-25 14:36
Articles in Press
2017-08-25 14:36
Publication Fee Transferred
2017-09-20 07:56
Edit the Manuscript by Language Editor
2017-09-26 04:15
Typeset the Manuscript
2017-10-23 03:21
Publish the Manuscript Online
2017-10-29 06:01
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Prostaglandin E1 protects hepatocytes against endoplasmic reticulum stress-induced apoptosis via protein kinase A-dependent induction of glucose-regulated protein 78 expression
Manuscript Source Unsolicited Manuscript
All Author List Fang-Wan Yang, Yu Fu, Ying Li, Yi-Huai He, Mao-Yuan Mu, Qi-Chuan Liu, Jun Long and Shi-De Lin
ORCID
Author(s) ORCID Number
Shi-De Lin http://orcid.org/0000-0001-8803-4069
Funding Agency and Grant Number
Funding Agency Grant Number
the Funds of Chinese National Natural Science Foundation Project (81160067/H0318, 814600124/H0316,)
Corresponding Author Shi-De Lin, MD, Chief Doctor, Professor, Department of Infectious Diseases, Affiliated Hospital of Zunyi Medical College, 201 Dalian street, Zunyi 563003, Guizhou Province, China. linshide6@hotmail.com
Key Words Hepatocytes; ER stress; Thapsigargin; Glucose-regulated protein (GRP) 78; Protein kinase A; Apoptosis
Core Tip The mechanism underlying the hepatoprotective effect of prostaglandin E1 (PGE1) remains unclear. In this study, we found that pretreatment with PGE1 protected hepatocytes against thapsigargin-induced apoptosis. PGE1 alone induced protein and mRNA expressions of glucose-regulated protein (GRP) 78. Treatment with protein kinase A (PKA)-inhibitor H89, KT5720 or siRNA specifically targeted against human GRP78 blocked PGE1-induced upregulation of GRP78. The hepatoprotective effect of PGE1 was lost by blocking GRP78 expression with either H89 or siRNA. Our study demonstrates for the first time that PGE1 protects against ER stress-induced hepatocyte apoptosis via PKA pathway-dependent induction of GRP78 expression.
Publish Date 2017-10-29 06:01
Citation Yang FW, Fu Y, Li Y, He YH, Mu MY, Liu QC, Long J, Lin SD. Prostaglandin E1 protects hepatocytes against endoplasmic reticulum stress-induced apoptosis via protein kinase A-dependent induction of glucose-regulated protein 78 expression. World J Gastroenterol 2017; 23(40): 7253-7264
URL http://www.wjgnet.com/1007-9327/full/v23/i40/7253.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i40.7253
Full Article (PDF) WJG-23-7253.pdf
Full Article (Word) WJG-23-7253.doc
Manuscript File 34639-Review.docx
Answering Reviewers 34639-Answering reviewers.pdf
Audio Core Tip 34639-Audio core tip.mp3
Biostatistics Review Certificate 34639-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 34639-Conflict-of-interest statement.pdf
Copyright License Agreement 34639-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 34639-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 34639-Institutional-Animal-Care-and-Use-Committee-Statement-revision.jpg
Institutional Review Board Approval Form or Document 34639-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 34639-Language certificate.pdf
Peer-review Report 34639-Peer-review(s).pdf
Scientific Misconduct Check 34639-Scientific misconduct check.pdf
Scientific Editor Work List 34639-Scientific editor work list.pdf