Publication Name	World Journal of Gastroenterology
Manuscript ID	34639
Country	China

Received	2017-05-12 08:32
Peer-Review Started	2017-05-13 16:44
To Make the First Decision	2017-06-22 05:59
Return for Revision	2017-06-27 09:22
Revised	2017-07-24 09:16
Second Decision	2017-08-21 04:32
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-08-25 14:36
Articles in Press	2017-08-25 14:36
Publication Fee Transferred	2017-09-20 07:56
Edit the Manuscript by Language Editor	2017-09-26 04:15
Typeset the Manuscript	2017-10-23 03:21
Publish the Manuscript Online	2017-10-29 06:01

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Prostaglandin E1 protects hepatocytes against endoplasmic reticulum stress-induced apoptosis via protein kinase A-dependent induction of glucose-regulated protein 78 expression
Manuscript Source	Unsolicited Manuscript
All Author List	Fang-Wan Yang, Yu Fu, Ying Li, Yi-Huai He, Mao-Yuan Mu, Qi-Chuan Liu, Jun Long and Shi-De Lin
ORCID	Author(s) ORCID Number Shi-De Lin http://orcid.org/0000-0001-8803-4069
Funding Agency and Grant Number	Funding Agency Grant Number the Funds of Chinese National Natural Science Foundation Project (81160067/H0318, 814600124/H0316,)
Corresponding Author	Shi-De Lin, MD, Chief Doctor, Professor, Department of Infectious Diseases, Affiliated Hospital of Zunyi Medical College, 201 Dalian street, Zunyi 563003, Guizhou Province, China. linshide6@hotmail.com
Key Words	Hepatocytes; ER stress; Thapsigargin; Glucose-regulated protein (GRP) 78; Protein kinase A; Apoptosis
Core Tip	The mechanism underlying the hepatoprotective effect of prostaglandin E1 (PGE1) remains unclear. In this study, we found that pretreatment with PGE1 protected hepatocytes against thapsigargin-induced apoptosis. PGE1 alone induced protein and mRNA expressions of glucose-regulated protein (GRP) 78. Treatment with protein kinase A (PKA)-inhibitor H89, KT5720 or siRNA specifically targeted against human GRP78 blocked PGE1-induced upregulation of GRP78. The hepatoprotective effect of PGE1 was lost by blocking GRP78 expression with either H89 or siRNA. Our study demonstrates for the first time that PGE1 protects against ER stress-induced hepatocyte apoptosis via PKA pathway-dependent induction of GRP78 expression.
Publish Date	2017-10-29 06:01
Citation	Yang FW, Fu Y, Li Y, He YH, Mu MY, Liu QC, Long J, Lin SD. Prostaglandin E1 protects hepatocytes against endoplasmic reticulum stress-induced apoptosis via protein kinase A-dependent induction of glucose-regulated protein 78 expression. World J Gastroenterol 2017; 23(40): 7253-7264
URL	http://www.wjgnet.com/1007-9327/full/v23/i40/7253.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i40.7253

Full Article (PDF)	WJG-23-7253.pdf
Full Article (Word)	WJG-23-7253.doc
Manuscript File	34639-Review.docx
Answering Reviewers	34639-Answering reviewers.pdf
Audio Core Tip	34639-Audio core tip.mp3
Biostatistics Review Certificate	34639-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	34639-Conflict-of-interest statement.pdf
Copyright License Agreement	34639-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	34639-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	34639-Institutional-Animal-Care-and-Use-Committee-Statement-revision.jpg
Institutional Review Board Approval Form or Document	34639-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	34639-Language certificate.pdf
Peer-review Report	34639-Peer-review(s).pdf
Scientific Misconduct Check	34639-Scientific misconduct check.pdf
Scientific Editor Work List	34639-Scientific editor work list.pdf