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12/7/2017 10:00:55 AM | Browse: 267 | Download: 160
Publication Name World Journal of Clinical Cases
Manuscript ID 34667
Country of Manuscript Source Switzerland
Received
2017-05-15 01:36
Peer-Review Started
2017-05-17 07:17
To Make the First Decision
2017-06-14 00:47
Return for Revision
2017-06-16 06:03
Revised
2017-10-26 03:23
Second Decision
2017-11-06 08:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-11-10 18:33
Articles in Press
2017-11-10 18:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-12-06 07:10
Publish the Manuscript Online
2017-12-07 10:00
ISSN 2307-8960 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research and Experimental
Manuscript Type Case Report
Article Title Do you want to participate in a clinical study as a healthy control? - Risk or benefit?
Manuscript Source Unsolicited Manuscript
All Author List Hanna Giessen, Christian A Nebiker, Matthias Bruehlmeier, Stefan Spreitzer, Beat Mueller and Philipp Schuetz
ORCID
Author(s) ORCID Number
Hanna Giessen http://orcid.org/0000-0002-2412-7642
Christian A Nebiker http://orcid.org/0000-0002-7493-2850
Beat Mueller http://orcid.org/0000-0002-1986-2511
Philipp Schuetz http://orcid.org/0000-0001-7564-1468
Funding Agency and Grant Number
Corresponding author Philipp Schuetz, MD, Professor, Department of Internal Medicine, Kantonsspital Aarau, Tellstrasse 1, Aarau 5000, Switzerland. philipp.schuetz@ksa.ch
Keywords Medullary thyroid cancer; Procalcitonin; Thyroid nodes; Endocrinology; Public health; Healthy control
Core Tip A lady participating as healthy control in a study was found to suffer from a medullary thyroid cancer, a type of cancer in total surgical removal before the tumor has spread is the most important prognostic factor. The difficulty is the low diagnostic accuracy of ultrasound and procalcitonin-computed tomography scan, as well as the limitations of fine needle aspiration in a patient with several nodules. This case illustrates the consequences of volunteering as a “healthy control” in a clinical study. While early detection of the MCT was possible in our patient it paid off for her, but abnormal test results may also cause harm to patients if being false positive and leading to invasive procedures.
Publish Date 2017-12-07 10:00
Citation Giessen H, Nebiker CA, Bruehlmeier M, Spreitzer S, Mueller B, Schuetz P. Do you want to participate in a clinical study as a healthy control? - Risk or benefit? World J Clin Cases 2017; 5(12): 437-439
Url http://www.wjgnet.com/2307-8960/full/v5/i12/437.htm
DOI http://dx.doi.org/10.12998/wjcc.v5.i12.437
Full Article (PDF) WJCC-5-437.pdf
Full Article (Word) WJCC-5-437.doc
Manuscript File 34667-Review.doc
Answering Reviewers 34667-Answering reviewers.pdf
Audio Core Tip 34667-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 34667-Conflict-of-interest statement.pdf
Copyright License Agreement 34667-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) 34667-Informed consent statement.pdf
Supplementary Material 34667-Supplementary material.docx
Peer-review Report 34667-Peer-review(s).pdf
Scientific Misconduct Check 34667-Scientific misconduct check.pdf
Scientific Editor Work List 34667-Scientific editor work list.pdf