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Articles Published Processes
9/28/2017 10:01:54 AM | Browse: 1276 | Download: 1673
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Received |
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2017-05-18 00:57 |
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Peer-Review Started |
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2017-05-19 03:17 |
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To Make the First Decision |
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2017-06-22 00:39 |
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Return for Revision |
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2017-06-23 10:35 |
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Revised |
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2017-09-06 20:19 |
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Second Decision |
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2017-09-15 00:07 |
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Accepted by Journal Editor-in-Chief |
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2017-09-15 22:36 |
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Accepted by Executive Editor-in-Chief |
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2017-09-19 21:03 |
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Articles in Press |
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2017-09-19 21:03 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-09-26 09:13 |
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Publish the Manuscript Online |
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2017-09-28 10:01 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Intrahepatic vascular changes in non-alcoholic fatty liver disease: Potential role of insulin-resistance and endothelial dysfunction
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Marcos Pasarín, Juan G Abraldes, Eleonora Liguori, Beverley Kok and Vincenzo La Mura |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Vincenzo La Mura, MD, PhD, Assistant Professor, Internal Medicine, IRCCS San Donato, Department of Biomedical Sciences for Health, University of Milan, p.zza Edmondo Malan, 1, San Donato Milanese 20097, Italy. vincenzo.lamura@unimi.it |
| Key Words |
Non-alcoholic fatty liver disease; Endothelial dysfunction; Insulin resistance; Metabolic syndrome |
| Core Tip |
Insulin-resistance participates in the development of endothelial dysfunction and interferes with vascular homeostasis in patients with metabolic syndrome. This has been demonstrated in large conductance vessels, promoting atherosclerosis, but also occurs at a microcirculation level, suggesting an important role for Insulin in controlling vascular resistance and, finally, organ perfusion. We offer an overview of those pre-clinical and clinical studies exploring the liver microcirculation, and discuss the importance of early vascular changes induced by insulin-resistance in non-alcoholic fatty liver disease and in the most common chronic hepatitis in which Insulin-Resistance is a comorbidity. |
| Publish Date |
2017-09-28 10:01 |
| Citation |
Pasarín M, Abraldes JG, Liguori E, Kok B, La Mura V. Intrahepatic vascular changes in non-alcoholic fatty liver disease: Potential role of insulin-resistance and endothelial dysfunction. World J Gastroenterol 2017; 23(37): 6777-6787 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i37/6777.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i37.6777 |
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