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9/28/2017 10:01:54 AM | Browse: 452 | Download: 246
Publication Name World Journal of Gastroenterology
Manuscript ID 34669
Country/Territory Italy
Received
2017-05-18 00:57
Peer-Review Started
2017-05-19 03:17
To Make the First Decision
2017-06-22 00:39
Return for Revision
2017-06-23 10:35
Revised
2017-09-06 20:19
Second Decision
2017-09-15 00:07
Accepted by Journal Editor-in-Chief
2017-09-15 22:36
Accepted by Company Editor-in-Chief
2017-09-19 21:03
Articles in Press
2017-09-19 21:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-09-26 09:13
Publish the Manuscript Online
2017-09-28 10:01
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Intrahepatic vascular changes in non-alcoholic fatty liver disease: Potential role of insulin-resistance and endothelial dysfunction
Manuscript Source Invited Manuscript
All Author List Marcos Pasarín, Juan G Abraldes, Eleonora Liguori, Beverley Kok and Vincenzo La Mura
ORCID
Author(s) ORCID Number
Marcos Pasarín http://orcid.org/0000-0002-4122-1235
Juan G Abraldes http://orcid.org/0000-0002-4392-660X
Eleonora Liguori http://orcid.org/0000-0002-0244-927X
Beverley Kok http://orcid.org/0000-0002-1727-5030
Vincenzo La Mura http://orcid.org/0000-0003-4685-7184
Funding Agency and Grant Number
Corresponding author Vincenzo La Mura, MD, PhD, Assistant Professor, Internal Medicine, IRCCS San Donato, Department of Biomedical Sciences for Health, University of Milan, p.zza Edmondo Malan, 1, San Donato Milanese 20097, Italy. vincenzo.lamura@unimi.it
Keywords Non-alcoholic fatty liver disease; Endothelial dysfunction; Insulin resistance; Metabolic syndrome
Core Tip Insulin-resistance participates in the development of endothelial dysfunction and interferes with vascular homeostasis in patients with metabolic syndrome. This has been demonstrated in large conductance vessels, promoting atherosclerosis, but also occurs at a microcirculation level, suggesting an important role for Insulin in controlling vascular resistance and, finally, organ perfusion. We offer an overview of those pre-clinical and clinical studies exploring the liver microcirculation, and discuss the importance of early vascular changes induced by insulin-resistance in non-alcoholic fatty liver disease and in the most common chronic hepatitis in which Insulin-Resistance is a comorbidity.
Publish Date 2017-09-28 10:01
Citation Pasarín M, Abraldes JG, Liguori E, Kok B, La Mura V. Intrahepatic vascular changes in non-alcoholic fatty liver disease: Potential role of insulin-resistance and endothelial dysfunction. World J Gastroenterol 2017; 23(37): 6777-6787
Url http://www.wjgnet.com/1007-9327/full/v23/i37/6777.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i37.6777
Full Article (PDF) WJG-23-6777.pdf
Full Article (Word) WJG-23-6777.doc
Manuscript File 34669-Review.docx
Answering Reviewers 34669-Answering reviewers.pdf
Audio Core Tip 34669-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 34669-Conflict-of-interest statement.pdf
Copyright License Agreement 34669-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 34669_Grant and Funding.docx
Non-Native Speakers of English Editing Certificate 34669_Language certificate.docx
Peer-review Report 34669-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 34669-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 34669-Scientific misconduct check.pdf
Scientific Editor Work List 34669-Scientific editor work list.pdf