Publication Name	World Journal of Gastroenterology
Manuscript ID	3467
Country	China

Received	2013-05-01 14:17
Peer-Review Started	2013-05-02 16:35
To Make the First Decision	2013-05-28 12:02
Return for Revision	2013-05-28 15:40
Revised	2013-06-25 17:03
Second Decision	2013-07-17 18:19
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-07-18 13:37
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-08-01 15:33
Typeset the Manuscript	2013-08-07 17:46
Publish the Manuscript Online	2013-08-19 18:22

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Medicine, General & Internal
Manuscript Type	Autobiography
Article Title	Preclinical evaluation of herpes simplex virus armed with granulocyte-macrophage colony-stimulating factor in pancreatic carcinoma
Manuscript Source	Invited Manuscript
All Author List	Hao Liu, Shou-Jun Yuan, Ying-Tai Chen, Yi-Bin Xie, Liang Cui, Wei-Zhi Yang, De-Xuan Yang and Yan-Tao Tian
Funding Agency and Grant Number
Corresponding Author	Yan-Tao Tian, MD, Professor, Department of Abdominal Surgery, Cancer Hospital, Chinese Academy of Medical Science, Peking Union Medical College, 17 Nan-li, Pan Jia Yuan, Chaoyang District, Beijing 100021, China. tyt67@163.com
Key Words	Pancreatic carcinoma; Gene therapy; Animal test; Herpes-simplex-virus encoding granulocyte-macrophage colony-stimulating factor
Core Tip	Herpes-simplex-virus encoding granulocyte-macrophage colony-stimulating factor (HSVGM-CSF) is an engineered oncolytic virus. The key features of HSVGM-CSF include the deletion of both copies of 飦?34.5 and the ICP47 gene as well as interruption of the ICP6 gene and insertion of the therapeutic gene GM-CSF. Our study provides the first evidence that HSVGM-CSF could inhibit the growth of pancreatic cancer in a dose-dependent manner. Enhanced GM-CSF expression might be responsible for the phenomenon.
Publish Date	2013-08-19 18:22
Citation	Liu H, Yuan SJ, Chen YT, Xie YB, Cui L, Yang WZ, Yang DX, Tian YT. Preclinical evaluation of herpes simplex virus armed with granulocyte-macrophage colony-stimulating factor in pancreatic carcinoma. World J Gastroenterol 2013; 19(31): 5138-5143
URL	http://www.wjgnet.com/1007-9327/full/v19/i31/5138.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i31.5138

Full Article (PDF)	WJG-19-5138.pdf
Manuscript File	3467-Review.doc
Answering Reviewers	3467-Answering reviewers.pdf
Copyright License Agreement	3467-Copyright assignment.docx
Non-Native Speakers of English Editing Certificate	3467-Language certificate.docx
Peer-review Report	3467-Peer review(s).pdf
Scientific Editor Work List	3467-Scientific editor work list.doc