Publication Name	World Journal of Gastroenterology
Manuscript ID	34724
Country	Poland

Received	2017-05-23 01:07
Peer-Review Started	2017-05-23 14:52
To Make the First Decision	2017-06-22 01:02
Return for Revision	2017-06-23 09:12
Revised	2017-07-31 14:21
Second Decision	2017-08-09 01:38
Accepted by Journal Editor-in-Chief	2017-08-09 08:17
Accepted by Executive Editor-in-Chief	2017-08-15 15:15
Articles in Press	2017-08-15 15:15
Publication Fee Transferred	2017-10-12 03:28
Edit the Manuscript by Language Editor	2017-10-25 15:41
Typeset the Manuscript	2017-11-06 04:39
Publish the Manuscript Online	2017-11-12 06:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Intestinal epithelium, intraepithelial lymphocytes, and the gut microbiota – Key players in the pathogenesis of celiac disease
Manuscript Source	Unsolicited Manuscript
All Author List	Bożena Cukrowska, Agnieszka Sowińska, Joanna Beata Bierła, Elżbieta Czarnowska, Anna Rybak and Urszula Grzybowska-Chlebowczyk
ORCID	Author(s) ORCID Number Bożena Cukrowska http://orcid.org/0000-0001-6887-0094 Agnieszka Sowińska http://orcid.org/0000-0002-3684-7129 Joanna Beata Bierła http://orcid.org/0000-0002-5772-5091 Elżbieta Czarnowska http://orcid.org/0000-0002-1785-1405 Anna Rybak http://orcid.org/0000-0002-8233-5490 Urszula Grzybowska-Chlebowczyk http://orcid.org/0000-0002-9869-7461
Funding Agency and Grant Number	Funding Agency Grant Number The Children's Memorial Health Institute 236/15 The Children’s Memorial Health Institute 243/16 The Children’s Memorial Health Institute S147/2016
Corresponding Author	Bożena Cukrowska, MD, PhD, Professor, Department of Pathology, Laboratory of Immunology, The Children’s Memorial Health Institute, Aleja Dzieci Polskich 20, Warsaw 04-730, Poland. b.cukrowska@ipczd.pl
Key Words	Celiac disease; Intestinal microbiota; Epithelium; Intraepithelial lymphocytes; Intestinal barrier
Core Tip	There is evidence that the host-microbiota homeostasis is disrupted in Celiac disease (CD) patients. Dysbiosis, meaning an imbalance in the gut microbiota and its metabolome, may activate innate immunity leading to pro-inflammatory changes, which induces intraepithelial lymphocyte infiltration and epithelial barrier damage, ultimately resulting in increased transfer of gluten peptides and inflammatory activation leading to CD development. The intestinal microbiota also has a direct effect on the breakdown of gluten and formation of immunogenic peptides. As colonization of the gut with microorganisms may be dependent on genetic factors, future prophylactic strategies may focus on gut microbiota modulation in genetically predisposed infants.
Publish Date	2017-11-12 06:39
Citation	Cukrowska B, Sowińska A, Bierła JB, Czarnowska E, Rybak A, Grzybowska-Chlebowczyk U. Intestinal epithelium, intraepithelial lymphocytes and the gut microbiota - Key players in the pathogenesis of celiac disease. World J Gastroenterol 2017; 23(42): 7505-7518
URL	http://www.wjgnet.com/1007-9327/full/v23/i42/7505.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i42.7505

Full Article (PDF)	WJG-23-7505.pdf
Full Article (Word)	WJG-23-7505.doc
Manuscript File	34724-Review.doc
Answering Reviewers	34724-Answering-Reviewers-revision.docx
Audio Core Tip	34724-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	34724-Conflict-of-interest statement.pdf
Copyright License Agreement	34724-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	34724-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	34724-Language certificate.pdf
Peer-review Report	34724-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	34724-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	34724-Scientific misconduct check.pdf
Scientific Editor Work List	34724-Scientific editor work list.pdf