Publication Name	World Journal of Gastroenterology
Manuscript ID	34731
Country	United States

Received	2017-05-19 04:59
Peer-Review Started	2017-05-19 14:00
To Make the First Decision	2017-06-22 00:38
Return for Revision	2017-06-23 10:35
Revised	2017-06-30 21:24
Second Decision	2017-07-11 05:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-07-12 07:04
Articles in Press	2017-07-12 07:04
Publication Fee Transferred	2017-07-26 03:36
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-08-11 12:07
Publish the Manuscript Online	2017-08-19 11:33

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Fluctuation of zonulin levels in blood vs stability of antibodies
Manuscript Source	Unsolicited Manuscript
All Author List	Aristo Vojdani, Elroy Vojdani and Datis Kharrazian
ORCID	Author(s) ORCID Number Aristo Vojdani http://orcid.org/0000-0003-2925-9334 Elroy Vojdani http://orcid.org/0000-0001-8687-9762 Datis Kharrazian http://orcid.org/0000-0001-7985-476X
Funding Agency and Grant Number
Corresponding Author	Aristo Vojdani, MSc, PhD, Immunosciences Lab., Inc., 822 S. Robertson Blvd., Ste. 312, Los Angeles, CA 90035, United States. drari@msn.com
Key Words	Zonulin; Occludin; Tight junction protein; Intestinal barrier integrity; Celiac disease
Core Tip	We studied possible variability in zonulin levels vs measuring antibodies against zonulin and other tight junction proteins in blood. We found that fluctuations in zonulin level from hour-to-hour and day-to-day were too great to recommend it for assessing intestinal permeability. Measurement of IgG and IgA antibodies against tight junction proteins in controls and in celiac disease patients proved to be very stable and reproducible, and we recommend this method for such an assessment in future studies.
Publish Date	2017-08-19 11:33
Citation	Vojdani A, Vojdani E, Kharrazian D. Fluctuation of zonulin levels in blood vs stability of antibodies. World J Gastroenterol 2017; 23(31): 5669-5679
URL	http://www.wjgnet.com/1007-9327/full/v23/i31/5669.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i31.5669

Full Article (PDF)	WJG-23-5669.pdf
Full Article (Word)	WJG-23-5669.doc
Manuscript File	34731-Review.docx
Answering Reviewers	34731-Answering reviewers.pdf
Audio Core Tip	34731-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	34731-Conflict-of-interest statement.pdf
Copyright License Agreement	34731-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	34731-Institutional review board statement.pdf
Peer-review Report	34731-Peer-review(s).pdf
Scientific Misconduct Check	34731-Scientific misconduct check.pdf
Scientific Editor Work List	34731-Scientific editor work list.pdf