Publication Name	World Journal of Clinical Cases
Manuscript ID	34766
Country	Japan

Received	2017-06-01 01:23
Peer-Review Started	2017-06-03 06:46
To Make the First Decision	2017-06-27 01:44
Return for Revision	2017-06-28 11:10
Revised	2017-07-13 05:54
Second Decision	2017-08-30 04:34
Accepted by Journal Editor-in-Chief	2017-08-30 05:29
Accepted by Executive Editor-in-Chief	2017-09-13 19:37
Articles in Press	2017-09-13 19:37
Publication Fee Transferred	2017-10-29 06:13
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-11-10 01:16
Publish the Manuscript Online	2017-11-17 09:05

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Pathology
Manuscript Type	Case Report
Article Title	Case of gastric neuroendocrine carcinoma showing an interesting tumorigenic pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Noriyuki Uesugi, Ryo Sugimoto, Makoto Eizuka, Yasuko Fujita, Mitsumasa Osakabe, Keisuke Koeda, Takashi Kosaka, Shunichi Yanai, Kazuyuki Ishida, Akira Sasaki, Takayuki Matsumoto and Tamotsu Sugai
ORCID	Author(s) ORCID Number Noriyuki Uesugi http://orcid.org/0000-0002-4388-6660 Ryo Sugimoto http://orcid.org/0000-0002-9486-0823 Makoto Eizuka http://orcid.org/0000-0003-4815-1273 Yasuko Fujita http://orcid.org/0000-0002-3988-9076 Mitsumasa Osakabe http://orcid.org/0000-0002-1797-3189 Keisuke Koeda http://orcid.org/0000-0002-9302-302X Takashi Kosaka http://orcid.org/0000-0001-6091-7214 Shunichi Yanai http://orcid.org/0000-0003-1871-2412 Kazuyuki Ishida http://orcid.org/0000-0002-2804-4588 Akira Sasaki http://orcid.org/0000-0002-1346-5312 Takayuki Matsumoto http://orcid.org/0000-0001-9786-3854 Tamotsu Sugai http://orcid.org/0000-0002-4896-3557
Funding Agency and Grant Number
Corresponding Author	Tamotsu Sugai, MD, Professor, Department of Molecular Diagnostic Pathology, Iwate Medical University, 19-1, Morioka 020-8505, Japan. tsugai@iwate-med.ac.jp
Key Words	Stomach; Neuroendocrine tumor G2; Neuroendocrine tumor G3; Neuroendocrine carcinoma
Core Tip	Gastric neuroendocrine carcninoma (NEC) is typically generated by dedifferentiation of adenocarcinoma cells to endocrine cells. However, we experienced a case of gastric NEC possibly generated from the neuroendocrine tumor (NET) component. The present case demonstrated an unconventional carcinogenic pathway in neuroendocrine tumorigenesis. In addition, we analyzed allelic imbalance (AI) in NET and NEC components and provided important insights into neuroendocrine carcinogenesis.
Publish Date	2017-11-17 09:05
Citation	Uesugi N, Sugimoto R, Eizuka M, Fujita Y, Osakabe M, Koeda K, Kosaka T, Yanai S, Ishida K, Sasaki A, Matsumoto T, Sugai T. Case of gastric neuroendocrine carcinoma showing an interesting tumorigenic pathway. World J Clin Cases 2017; In press
URL	http://www.wjgnet.com/2307-8960/full/v5/i11/397.htm
DOI	http://dx.doi.org/10.12998/wjcc.v5.i11.397

Full Article (PDF)	WJCC-5-397.pdf
Full Article (Word)	WJCC-5-397.doc
Manuscript File	34766-Review.docx
Answering Reviewers	34766-Answering reviewers.pdf
Audio Core Tip	34766-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	34766-Conflict-of-interest statement.pdf
Copyright License Agreement	34766-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	34766-Approved-Grant-Application-Form(s)-or-Funding-Agency-Copy-of-any-Approval-Document(s)-revision.docx
Signed Informed Consent Form(s) or Document(s)	34766-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	34766-Language certificate.pdf
Peer-review Report	34766-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	34766-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	34766-Scientific misconduct check.pdf
Scientific Editor Work List	34766-Scientific editor work list.pdf