Publication Name	World Journal of Stem Cells
Manuscript ID	34815
Country	United States

Received	2017-05-31 01:52
Peer-Review Started	2017-06-01 13:30
To Make the First Decision	2017-07-10 00:48
Return for Revision	2017-07-17 00:42
Revised	2017-08-10 03:11
Second Decision	2017-08-25 07:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-09-04 18:41
Articles in Press	2017-09-04 18:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-11-23 00:17
Publish the Manuscript Online	2017-11-23 01:13

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cell Biology
Manuscript Type	Therapeutics Advances
Article Title	Amyotrophic lateral sclerosis as a protein level, non-genomic disease: Therapy with S2RM exosome released molecules
Manuscript Source	Invited Manuscript
All Author List	Greg Maguire
ORCID	Author(s) ORCID Number Greg Maguire http://orcid.org/0000-0001-5484-6157
Funding Agency and Grant Number
Corresponding Author	Greg Maguire, Doctor, BioRegenerative Sciences, Inc., 505 Coast Blvd, La Jolla, CA 92037, United States. gmaguire@bioregenerativesciences.com
Key Words	Amyotrophic lateral sclerosis; Proteins; Stem cells; Extracellular matrix; Exposome; Heat shock protein; Stem cell molecules
Core Tip	The author propose that amyotrophic lateral sclerosis is a disease of damaged and misfolded proteins induced by environmental regulators, occurring at the level of translation and post-translation, and not at the level of the genome. The damaged proteins disrupt the extracellular matrix surrounding neurons, precluding normal communication between neurons and the neural stem cells that surround the neurons. As a consequence, the neural stem cells no longer properly shuttle heat shock proteins to the neurons, and many proteins within the neuron misfold. The misfolded proteins are prion-like, leading to a spreading, destructive sequelae within and between neurons and other cells in the nervous system.
Publish Date	2017-11-23 01:13
Citation	Maguire G. Amyotrophic lateral sclerosis as a protein level, non-genomic disease: Therapy with S2RM exosome released molecules. World J Stem Cells 2017; 9(11): 187-202
URL	http://www.wjgnet.com/1948-0210/full/v9/i11/187.htm
DOI	http://dx.doi.org/10.4252/wjsc.v9.i11.187

Full Article (PDF)	WJSC-9-187.pdf
Full Article (Word)	WJSC-9-187.doc
Manuscript File	34815-Review.docx
Answering Reviewers	34815-Answering reviewers.pdf
Audio Core Tip	34815-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	34815-Conflict-of-interest statement.pdf
Copyright License Agreement	34815-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	34815-Approved-Grant-Application-Form(s)-or-Funding-Agency-Copy-of-any-Approval-Document(s)-revision.docx
Non-Native Speakers of English Editing Certificate	34815-Non-Native-Speakers-of-English-revision.docx
Peer-review Report	34815-Peer-review(s).pdf
Scientific Misconduct Check	34815-Scientific misconduct check.pdf
Scientific Editor Work List	34815-Scientific editor work list.pdf