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12/5/2017 1:55:00 AM | Browse: 928 | Download: 1497
Publication Name World Journal of Hepatology
Manuscript ID 34826
Country/Territory Italy
Received
2017-05-31 01:50
Peer-Review Started
2017-06-01 13:39
To Make the First Decision
2017-07-10 00:47
Return for Revision
2017-07-20 02:31
Revised
2017-08-02 15:27
Second Decision
2017-09-14 07:09
Accepted by Journal Editor-in-Chief
2017-09-14 09:41
Accepted by Company Editor-in-Chief
2017-10-16 06:38
Articles in Press
2017-10-16 06:38
Publication Fee Transferred
2017-11-06 17:50
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-11-28 04:20
Publish the Manuscript Online
2017-12-05 01:55
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Observational Study
Article Title Liver decompensation predicts ribavirin overexposure in hepatitis C virus patients treated with direct-acting antivirals
Manuscript Source Unsolicited Manuscript
All Author List Viola Guardigni, Lorenzo Badia, Matteo Conti, Matteo Rinaldi, Rita Mancini, Pierluigi Viale and Gabriella Verucchi
ORCID
Author(s) ORCID Number
Viola Guardigni http://orcid.org/0000-0002-2769-7325
Lorenzo Badia http://orcid.org/0000-0001-5694-1158
Matteo Conti http://orcid.org/0000-0002-1579-9674
Matteo Rinaldi http://orcid.org/0000-0002-3568-5973
Rita Mancini http://orcid.org/0000-0002-5491-2449
Pierluigi Viale http://orcid.org/0000-0003-1264-0008
Gabriella Verucchi http://orcid.org/0000-0001-6546-0495
Funding Agency and Grant Number
Corresponding Author Viola Guardigni, MD, Department of Medical and Surgical Sciences, University of Bologna, S. Orsola-Malpighi Hospital, via G. Massarenti 9, Bologna 40138, Italy. viola.guardigni2@unibo.it
Key Words Hepatitis C; Direct-acting antivirals; Ribavirin; Therapeutic drug monitoring; Decompensated cirrhosis
Core Tip In this study, patients with decompensated cirrhosis displayed higher plasma ribavirin concentrations in comparison to compensated patients, when treated with Interferon-free regimens for hepatitis C. Higher ribavirin levels were found to lead to greater rates of related toxicities and Child-Pugh class resulted independently associated with ribavirin plasma levels, in our population. Our findings suggest that ribavirin concentrations should be strictly monitored in subjects with advanced liver disease, during direct-acting antivirals-treatment. An early dosage adjustment of ribavirin should be performed when high levels of this antiviral are detected in patients’ plasma, in order to avoid toxicities among these frail individuals.
Publish Date 2017-12-05 01:55
Citation Guardigni V, Badia L, Conti M, Rinaldi M, Mancini R, Viale P, Verucchi G. Liver decompensation predicts ribavirin overexposure in hepatitis C virus patients treated with direct-acting antivirals. World J Hepatol 2017; 9(34): 1270-1277
URL http://www.wjgnet.com/1948-5182/full/v9/i34/1270.htm
DOI http://dx.doi.org/10.4254/wjh.v9.i34.1270
Full Article (PDF) WJH-9-1270.pdf
Full Article (Word) WJH-9-1270.doc
Manuscript File 34826-Review.doc
Answering Reviewers 34826-Answering reviewers.pdf
Audio Core Tip 34826-Audio core tip.mp3
Biostatistics Review Certificate 34826-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 34826-Conflict-of-interest statement.pdf
Copyright License Agreement 34826-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) 34826-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 34826-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 34826-Language certificate.pdf
Peer-review Report 34826-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 34826-Journal editor-in-chief review report.pdf
Scientific Editor Work List 34826-Scientific editor work list.pdf