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11/1/2017 9:02:15 AM | Browse: 1045 | Download: 1486
Publication Name World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID 34856
Country/Territory Greece
Received
2017-06-08 01:17
Peer-Review Started
2017-06-08 07:33
To Make the First Decision
2017-08-08 01:09
Return for Revision
2017-08-08 08:03
Revised
2017-08-21 08:18
Second Decision
2017-09-08 09:09
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-09-15 00:35
Articles in Press
2017-09-15 00:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-10-31 03:56
Publish the Manuscript Online
2017-11-01 09:02
ISSN 2150-5349 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Case Control Study
Article Title Association of miR-146 rs2910164, miR-196a rs11614913, miR-221 rs113054794 and miR-224 rs188519172 polymorphisms with anti-TNF treatment response in a Greek population with Crohn’s disease
Manuscript Source Invited Manuscript
All Author List Ioannis Papaconstantinou, Christina Kapizioni, Evangelia Legaki, Elena Xourgia, George Karamanolis, Antonios Gklavas and Maria Gazouli
ORCID
Author(s) ORCID Number
Ioannis Papaconstantinou http://orcid.org/0000-0002-4614-9041
Christina Kapizioni http://orcid.org/0000-0001-9491-2278
Evangelia Legaki http://orcid.org/0000 0003 4261 2745
Elena Xourgia http://orcid.org/0000-0001-5766-3209
George Karamanolis http://orcid.org/0000-0001-9872-1276
Antonios Gklavas http://orcid.org/0000-0001-5997-6137
Maria Gazouli http://orcid.org/0000-0002-3295-6811
Funding Agency and Grant Number
Corresponding Author Maria Gazouli, Associate Professor, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Michalakopoulou 176, Athens 11527, Greece. mgazouli@med.uoa.gr
Key Words MicroRNA; Crohn’s disease; Polymorphisms; Anti-TNF; Biomarkers
Core Tip Anti-TNF agents are the cornerstone of inflammatory bowel disease (IBD) treatment strategy so far though not effective in one third of patients in the first months of administration. Biomarkers for prediction of each patient’s treatment response are vigorously sought in the era of personalized medicine. MicroRNAs have been studied as possible predictors of response to therapy in cancer and autoimmune diseases including IBD. MiRNA polymorphisms though have never been studied in IBD as markers of anti-TNF response. Our results suggest that for rs2910164, rs11614913, rs113054794, and rs188519172 no association to anti-TNF agents’ response in patients with Crohn’s disease can be established.
Publish Date 2017-11-01 09:02
Citation Papaconstantinou I, Kapizioni C, Legaki E, Xourgia E, Kara¬manolis G, Gklavas A, Gazouli M. Association of miR-146 rs2910164, miR-196a rs11614913, miR-221 rs113054794 and miR-224 rs188519172 polymorphisms with anti-TNF treatment response in a Greek population with Crohn’s disease. World J Gastrointest Pharmacol Ther 2017; 8(4): 193-200
URL http://www.wjgnet.com/2150-5349/full/v8/i4/193.htm
DOI http://dx.doi.org/10.4292/wjgpt.v8.i4.193
Full Article (PDF) WJGPT-8-193.pdf
Full Article (Word) WJGPT-8-193.doc
Manuscript File 34856-Review.docx
Answering Reviewers 34856-Answering reviewers.pdf
Audio Core Tip 34856-Audio core tip.mp3
Biostatistics Review Certificate 34856-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 34856-Conflict-of-interest statement.pdf
Copyright License Agreement 34856-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) 34856-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 34856-Institutional review board statement.pdf
Peer-review Report 34856-Peer-review(s).pdf
Scientific Editor Work List 34856-Scientific editor work list.pdf