Publication Name	World Journal of Gastroenterology
Manuscript ID	34869
Country	China

Received	2017-05-31 01:30
Peer-Review Started	2017-05-31 01:47
To Make the First Decision	2017-06-22 02:40
Return for Revision	2017-06-22 04:25
Revised	2017-07-03 10:34
Second Decision	2017-07-06 11:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-07-12 04:15
Articles in Press	2017-07-12 04:15
Publication Fee Transferred	2017-07-12 13:03
Edit the Manuscript by Language Editor	2017-07-23 03:01
Typeset the Manuscript	2017-08-14 06:45
Publish the Manuscript Online	2017-08-19 11:33

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Threonine and tyrosine kinase may serve as a prognostic biomarker for gallbladder cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Yuan Xie, Jian-Zhen Lin, An-Qiang Wang, Wei-Yu Xu, Jun-Yu Long, Yu-Feng Luo, Jie Shi, Zhi-Yong Liang, Xin-Ting Sang and Hai-Tao Zhao
ORCID	Author(s) ORCID Number Yuan Xie http://orcid.org/0000-0001-9080-7358 Jian-Zhen Lin http://orcid.org/0000-0002-4767-8834 An-Qiang Wang http://orcid.org/0000-0002-9823-1880 Wei-Yu Xu http://orcid.org/0000-0002-2101-4829 Jun-Yu Long http://orcid.org/0000-0001-5745-7165 Yu-Feng Luo http://orcid.org/0000-0002-6984-0206 Jie Shi http://orcid.org/0000-0002-5218-6236 Zhi-Yong Liang http://orcid.org/0000-0003-4787-2925 Xin-Ting Sang http://orcid.org/0000-0003-1952-0527 Hai-Tao Zhao http://orcid.org/0000-0002-3444-8044
Funding Agency and Grant Number	Funding Agency Grant Number International Science and Technology Cooperation Projects 2015DFA30650 International Science and Technology Cooperation Projects 2016YFE0107100 The Capital Special Research Project for the clinical application Z151100004015170 Capital Special Research Project for Health Development 2014-2-4012 Beijing Nature Science Foundation for Young Scholars Project 7164293
Corresponding Author	Hai-Tao Zhao, MD, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Shuaifuyuan, Wangfujing, Beijing 100730, China. zhaoht@pumch.cn
Key Words	Threonine and tyrosine kinase; Biomarker; Prognosis; Gallbladder cancer
Core Tip	Numerous studies demonstrate that high levels of threonine and tyrosine kinase (TTK) are present in many types of human malignancies, and its overexpression closely correlates with early recurrence and poor survival. However, no prior studies have attempted to concentrate on the expression of TTK in patients with gallbladder cancer (GBC). In this study, we detected the expression of TTK in GBC specimens and analyzed the associations between TTK expression and clinicopathological parameters and clinical prognosis.
Publish Date	2017-08-19 11:33
Citation	Xie Y, Lin JZ, Wang AQ, Xu WY, Long JY, Luo YF, Shi J, Liang ZY, Sang XT, Zhao HT. Threonine and tyrosine kinase may serve as a prognostic biomarker for gallbladder cancer. World J Gastroenterol 2017; 23(31): 5787-5797
URL	http://www.wjgnet.com/1007-9327/full/v23/i31/5787.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i31.5787

Full Article (PDF)	WJG-23-5787.pdf
Full Article (Word)	WJG-23-5787.doc
Manuscript File	34869-Review.docx
Answering Reviewers	34869-Answering reviewers.pdf
Audio Core Tip	34869-Audio core tip.mp3
Biostatistics Review Certificate	34869-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	34869-Conflict-of-interest statement.pdf
Copyright License Agreement	34869-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	34869-Grant Application Form(s).pdf
Signed Informed Consent Form(s) or Document(s)	34869-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	34869-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	34869-Language certificate.pdf
Peer-review Report	34869-Peer-review(s).pdf
Scientific Misconduct Check	34869-Scientific misconduct check.pdf
Scientific Editor Work List	34869-Scientific editor work list.pdf