| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Natural history of covert hepatic encephalopathy: An observational study of 366 cirrhotic patients
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
An-Jiang Wang, A-Ping Peng, Bi-Min Li, Na Gan, Li Pei, Xue-Lian Zheng, Jun-Bo Hong, Hai-Ying Xiao, Jia-Wei Zhong and Xuan Zhu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Planning Project of Health and Family Planning Commission of Jiangxi Province |
20171022 |
| National Natural Science Fund of China |
81460122 |
| Project in the Science and Technology Pillar Program of Jiangxi Provincial Department of Science and Technology |
20161BBG70166 |
| Jiangxi Provincial Outstanding Young Talent Program |
20171BCB23085 |
| Natural Science Fund of Jiangxi Province For Young Scholars |
20171BAB215008 |
|
| Corresponding Author |
Xuan Zhu, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology and Hepatology, the First Affiliated Hospital of Nanchang University, 17 Yongwai Zheng Street, Nanchang 330006, Jiangxi Province, China. ndyfy0326@ncu.edu.cn |
| Key Words |
Covert hepatic encephalopathy; Overt hepatic encephalopathy; Natural history; Liver cirrhosis |
| Core Tip |
Covert hepatic encephalopathy (CHE) was prevalent in clinically-stable cirrhosis in the tertiary care hospital. A history of overt hepatic encephalopathy (OHE) was the only risk factor for CHE in patients with OHE history, while a high model for end-stage liver disease score was the only risk factor for those without OHE history. Natural history of CHE in the absence of medication intervention included development of complications, persistence or spontaneous resolution of CHE. Triage of patients based on predictors for exacerbation and resolution, rather than the degree of impairment in daily work productivity or quality of life, could make clinical management of CHE more cost-effective. |
| Publish Date |
2017-09-14 03:13 |
| Citation |
Wang AJ, Peng AP, Li BM, Gan N, Pei L, Zheng XL, Hong JB, Xiao HY, Zhong JW, Zhu X. Natural history of covert hepatic encephalopathy: An observational study of 366 cirrhotic patients. World J Gastroenterol 2017; 23(34): 6321-6329 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i34/6321.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i34.6321 |
