Publication Name	World Journal of Gastroenterology
Manuscript ID	3491
Country	Germany

Received	2013-05-02 09:58
Peer-Review Started	2013-05-02 15:05
To Make the First Decision	2013-06-09 09:58
Return for Revision	2013-06-20 20:11
Revised	2013-08-15 03:56
Second Decision	2013-09-29 12:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-09-29 22:18
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-12-19 17:28
Publish the Manuscript Online	2014-01-14 20:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Autobiography
Article Title	Inhibitor of differentiation proteins do not influence prognosis of biliary tract cancer
Manuscript Source	Invited Manuscript
All Author List	Jan Harder, Michael J Müller, Matthias Fuchs, Vera Gumpp, Annette Schmitt-Graeff, Richard Fischer, Melanie Frank, Oliver Opitz and Jens Hasskarl
Funding Agency and Grant Number
Corresponding Author	Jan Harder, MD, Department of Gastroenterology, Hematology and Oncology, Hegau-Bodensee-Hochrhein Kliniken, Virchowstraße 10, 78221 Singen, Germany. jan.harder@hbh-kliniken.de
Key Words	Biliary tract cancer; Cholangiocarcinoma; Inhibitor of differentiation; Prognostic factors
Core Tip	Cholangiocarcinoma present as heterogeneous tumors with generally poor prognosis. Molecular changes that drive tumor development are poorly understood, and no valid prognostic markers other than stage and performance status have been identified. Here we analyzed the protein expression of the four inhibitor of differentiation (ID)-proteins by immunohistochemistry in 129 patients with advanced biliary tract cancer, which showed a deregulated ID protein expression in cancer cells and this protein expression partly correlated with the overall survival of patients. Therefore the ID-proteins maybe useful prognostic markers.
Publish Date	2014-01-14 20:11
Citation	Harder J, Müller MJ, Fuchs M, Gumpp V, Schmitt-Graeff A, Fischer R, Frank M, Opitz O, Hasskarl J. Inhibitor of differentiation proteins do not influence prognosis of biliary tract cancer. World J Gastroenterol 2013; 19(48): 9334-9342
URL	http://www.wjgnet.com/1007-9327/full/v19/i48/9334.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i48.9334

Full Article (PDF)	WJG-19-9334.pdf
Manuscript File	3491-Review.doc
Answering Reviewers	3491-Copyright assignment.pdf
Copyright License Agreement	3491-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethikvotum.pdf
Peer-review Report	3491-Peer review(s).pdf
Scientific Editor Work List	3491-Scientific editor work list.doc