Publication Name	World Journal of Gastroenterology
Manuscript ID	34921
Country	Japan

Received	2017-06-29 01:17
Peer-Review Started	2017-06-30 08:38
To Make the First Decision	2017-07-27 07:56
Return for Revision	2017-08-01 11:25
Revised	2017-09-08 15:59
Second Decision	2017-09-15 00:07
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-09-19 21:01
Articles in Press	2017-09-19 21:01
Publication Fee Transferred	2017-09-27 12:40
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-11-06 04:39
Publish the Manuscript Online	2017-11-12 06:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Basic Study
Article Title	Nuclear heat shock protein 110 expression is associated with poor prognosis and hyperthermo-chemotherapy resistance in gastric cancer patients with peritoneal metastasis
Manuscript Source	Unsolicited Manuscript
All Author List	Akiharu Kimura, Kyoichi Ogata, Bolag Altan, Takehiko Yokobori, Erito Mochiki, Mitsuhiro Yanai, Norimichi Kogure, Toru Yanoma, Masaki Suzuki, Tuya Bai and Hiroyuki Kuwano
ORCID	Author(s) ORCID Number Akiharu Kimura http://orcid.org/0000-0002-6832-4146 Kyoichi Ogata http://orcid.org/0000-0001-8059-159X Bolag Altan http://orcid.org/0000-0002-2222-0966 Takehiko Yokobori http://orcid.org/0000-0003-3284-4796 Erito Mochiki http://orcid.org/0000-0001-5991-4913 Mitsuhiro Yanai http://orcid.org/0000-0002-2627-5665 Norimichi Kogure http://orcid.org/0000-0001-5046-8742 Toru Yanoma http://orcid.org/0000-0003-2513-6521 Masaki Suzuki http://orcid.org/0000-0002-1503-6861 Tuya Bai http://orcid.org/0000-0003-4815-5450 Hiroyuki Kuwano http://orcid.org/0000-0003-1809-8483
Funding Agency and Grant Number
Corresponding Author	Akiharu Kimura, MD, PhD, Senior Lecturer, Department of General Surgical Science, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan. akimura@gunma-u.ac.jp
Key Words	Peritoneal metastasis; Hyperthermia; Hyperthermo-chemotherapy; Heat shock protein 110; Gastric cancer; Drug resistance
Core Tip	Gastric cancer remains one of the most common cancers worldwide. Peritoneal dissemination is the most common reason behind gastric cancer (GC) recurrence, and the median survival duration for patients with metastatic and recurrent GC is only 13–16 mo. In our department, we have used intraperitoneal hyperthermo-chemotherapy in patients with advanced rectal cancer and GC with peritoneal metastasis. In this study, we evaluated the significance of heat shock protein 110 (HSP110) expression in GC patients with peritoneal metastasis and assessed the effects of HSP110 suppression on hyperthermo-chemotherapy sensitivity in vitro.
Publish Date	2017-11-12 06:39
Citation	Kimura A, Ogata K, Altan B, Yokobori T, Mochiki E, Yanai M, Kogure N, Yanoma T, Suzuki M, Bai T, Kuwano H. Nuclear heat shock protein 110 expression is associated with poor prognosis and hyperthermo-chemotherapy resistance in gastric cancer patients with peritoneal metastasis. World J Gastroenterol 2017; 23(42): 7541-7550
URL	http://www.wjgnet.com/1007-9327/full/v23/i42/7541.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i42.7541

Full Article (PDF)	WJG-23-7541.pdf
Full Article (Word)	WJG-23-7541.doc
Manuscript File	34921-Review.docx
Answering Reviewers	34921-Answering reviewers.pdf
Audio Core Tip	34921-Audio core tip.mp3
Biostatistics Review Certificate	34921-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	34921-Conflict-of-interest statement.pdf
Copyright License Agreement	34921-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	34921-Approved-Grant-Application-Form(s)-or-Funding-Agency-Copy-of-any-Approval-Document(s).doc
Institutional Animal Care and Use Committee Approval Form or Document	34921-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	34921-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	34921-Non-Native-Speakers-of-English-revision.pdf
Peer-review Report	34921-Peer-review(s).pdf
Scientific Misconduct Check	34921-Scientific misconduct check.pdf
Scientific Editor Work List	34921-Scientific editor work list.pdf