Publication Name	World Journal of Gastroenterology
Manuscript ID	34992
Country	Malaysia

Received	2017-06-09 00:37
Peer-Review Started	2017-06-10 00:39
To Make the First Decision	2017-07-13 05:04
Return for Revision	2017-07-17 11:54
Revised	2017-08-03 02:33
Second Decision	2017-08-15 07:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-08-15 15:07
Articles in Press	2017-08-15 15:07
Publication Fee Transferred	2017-09-19 11:16
Edit the Manuscript by Language Editor	2017-09-29 01:45
Typeset the Manuscript	2017-11-02 10:10
Publish the Manuscript Online	2017-11-20 04:03

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Chronic liver disease is universal in children with biliary atresia living with native liver
Manuscript Source	Unsolicited Manuscript
All Author List	Way Seah Lee, Sik Yong Ong, Hee Wei Foo, Shin Yee Wong, Chen Xi Kong, Ru Bin Seah and Ruey Terng Ng
ORCID	Author(s) ORCID Number Way Seah Lee http://orcid.org/0000-0001-9163-2828 Sik Yong Ong http://orcid.org/0000-0001-9647-5788 Shin Yee Wong http://orcid.org/0000-0002-7486-0594
Funding Agency and Grant Number	Funding Agency Grant Number University Malaya High Impact Research (UM.C/625/HIR/MOHE/CHAN/13/1) from Ministry of Higher Education, Malaysia
Corresponding Author	Way Seah Lee, MBBS, MD, Professor, Department of Paediatrics, University Malaya Medical Centre, Kuala Lumpur 50603, Malaysia. leews@um.edu.my
Key Words	Biliary atresia; Medical status; Chronic liver disease
Core Tip	Previous study showed that more than 90% of children with biliary atresia (BA) surviving with native livers have clinical and laboratory evidence of chronic liver disease (CLD). In the present cohort, we found that 71% of patients with BA living with native livers had no clinical complications of CLD and 90% had normal liver synthetic function, only 2% had ideal medical outcome. Common medical complications encountered were cholangitis, portal hypertension and bleeding oesophageal varices. Portal hypertension and bleeding oesophageal varices were seen in 12% and 6% of children younger than 5 years of age. Medical surveillance in children with BA after Kasai surgery for medical complications should start even before 5 years of age.
Publish Date	2017-11-20 04:03
Citation	Lee WS, Ong SY, Foo HW, Wong SY, Kong CX, Seah RB, Ng RT. Chronic liver disease is universal in children with biliary atresia living with native liver. World J Gastroenterol 2017; 23(43): 7776-7784
URL	http://www.wjgnet.com/1007-9327/full/v23/i43/7776.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i43.7776

Full Article (PDF)	WJG-23-7776.pdf
Full Article (Word)	WJG-23-7776.doc
Manuscript File	34992-Review.docx
Answering Reviewers	34992-Answering reviewers.pdf
Audio Core Tip	34992-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	34992-Conflict-of-interest statement.pdf
Copyright License Agreement	34992-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	34992-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	34992-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	34992_Ethical Approval BA Medical Status.pdf
Non-Native Speakers of English Editing Certificate	34992_BA Status WJG Language Certificate.pdf
Peer-review Report	34992-Peer-review(s).pdf
Scientific Misconduct Check	34992-Scientific misconduct check.pdf
Scientific Editor Work List	34992-Scientific editor work list.pdf