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11/5/2017 12:48:27 AM | Browse: 251 | Download: 229
Publication Name World Journal of Gastroenterology
Manuscript ID 35070
Country of Manuscript Source Hungary
Received
2017-06-15 10:10
Peer-Review Started
2017-06-16 07:07
To Make the First Decision
2017-07-13 05:40
Return for Revision
2017-07-13 08:29
Revised
2017-07-26 20:08
Second Decision
2017-08-21 07:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-08-25 14:29
Articles in Press
2017-08-25 14:29
Publication Fee Transferred
2017-09-29 05:32
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-10-30 03:15
Publish the Manuscript Online
2017-11-05 00:48
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, and build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Authors 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Region-dependent effects of diabetes and insulin-replacement on neuronal nitric oxide synthase- and heme oxygenase-immunoreactive submucous neurons
Manuscript Source Unsolicited Manuscript
All Author List Nikolett Bódi, Zita Szalai, Lalitha Chandrakumar and Mária Bagyánszki
ORCID
Author(s) ORCID Number
Nikolett Bódi http://orcid.org/0000-0002-9774-1387
Zita Szalai http://orcid.org/0000-0002-8722-0211
Lalitha Chandrakumar http://orcid.org/0000-0003-3674-5306
Mária Bagyánszki http://orcid.org/0000-0003-3533-9461
Funding Agency and Grant Number
Funding Agency Grant Number
Hungarian Scientific Research Fund, OTKA grant PD 108309
the János Bolyai Research Scholarship of the Hungarian Academy of Sciences
the Stipendium Hungaricum Scholarship 2015-SH-500041
Corresponding author Mária Bagyánszki, PhD, Associate Professor, Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged H-6726, Hungary. bmarcsi@bio.u-szeged.hu
Keywords Submucous neurons; Nitrergic neurons; Heme oxygenase 1; Heme oxygenase 2; Gut region-specificity; Diabetes; Insulin
Core Tip Our present findings demonstrate for the first time the segment–specific alterations of the proportion of nitrergic, heme oxygenase (HO)1-immunoreactive (IR) and HO2-IR neurons in the submucous plexus of control, diabetic and insulin-treated diabetic rats. Our results suggest that duodenal nitrergic neurons are not affected, but ileal and colonic ones are induced to change their neurochemical character in diabetes and insulin replacement. The colonic ganglia are abundant in HO-IR neurons in both controls and diabetics, whereas insulin treatment decreases their proportion. In contrast to the colon, the low amount of HO-IR ileal neurons was increased by insulin-treatment.
Publish Date 2017-11-05 00:48
Citation Bódi N, Szalai Z, Chandrakumar L, Bagyánszki M. Region-dependent effects of diabetes and insulin-replacement on neuronal nitric oxide synthase- and heme oxygenase-immunoreactive submucous neurons. World J Gastroenterol 2017; 23(41): 7359-7368
Url http://www.wjgnet.com/1007-9327/full/v23/i41/7359.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i41.7359
Full Article (PDF) WJG-23-7359.pdf
Full Article (Word) WJG-23-7359.doc
Manuscript File 35070-Review.doc
Answering Reviewers 35070-Answering reviewers.pdf
Audio Core Tip 35070-Audio core tip.mp3
Biostatistics Review Certificate 35070-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 35070-Conflict-of-interest statement.pdf
Copyright License Agreement 35070-Copyright assignment.pdf
Data Sharing Statement 35070-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 35070-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 35070-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 35070-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 35070-Language certificate.PDF
Scientific Research Process 35070-Scientific research process.pdf
Peer-review Report 35070-Peer-review(s).pdf
Scientific Misconduct Check 35070-Scientific misconduct check.pdf
Scientific Editor Work List 35070-Scientific editor work list.pdf