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Articles Published Processes
11/5/2017 12:48:27 AM | Browse: 1091 | Download: 1895
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Received |
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2017-06-15 10:10 |
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Peer-Review Started |
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2017-06-16 07:07 |
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To Make the First Decision |
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2017-07-13 05:40 |
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Return for Revision |
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2017-07-13 08:29 |
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Revised |
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2017-07-26 20:08 |
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Second Decision |
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2017-08-21 07:06 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-08-25 14:29 |
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Articles in Press |
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2017-08-25 14:29 |
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Publication Fee Transferred |
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2017-09-29 05:32 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-10-30 03:15 |
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Publish the Manuscript Online |
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2017-11-05 00:48 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, and build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Authors 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Region-dependent effects of diabetes and insulin-replacement on neuronal nitric oxide synthase- and heme oxygenase-immunoreactive submucous neurons
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Nikolett Bódi, Zita Szalai, Lalitha Chandrakumar and Mária Bagyánszki |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Hungarian Scientific Research Fund, OTKA grant |
PD 108309 |
| the János Bolyai Research Scholarship of the Hungarian Academy of Sciences |
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| the Stipendium Hungaricum Scholarship |
2015-SH-500041 |
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| Corresponding Author |
Mária Bagyánszki, PhD, Associate Professor, Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged H-6726, Hungary. bmarcsi@bio.u-szeged.hu |
| Key Words |
Submucous neurons; Nitrergic neurons; Heme oxygenase 1; Heme oxygenase 2; Gut region-specificity; Diabetes; Insulin |
| Core Tip |
Our present findings demonstrate for the first time the segment–specific alterations of the proportion of nitrergic, heme oxygenase (HO)1-immunoreactive (IR) and HO2-IR neurons in the submucous plexus of control, diabetic and insulin-treated diabetic rats. Our results suggest that duodenal nitrergic neurons are not affected, but ileal and colonic ones are induced to change their neurochemical character in diabetes and insulin replacement. The colonic ganglia are abundant in HO-IR neurons in both controls and diabetics, whereas insulin treatment decreases their proportion. In contrast to the colon, the low amount of HO-IR ileal neurons was increased by insulin-treatment. |
| Publish Date |
2017-11-05 00:48 |
| Citation |
Bódi N, Szalai Z, Chandrakumar L, Bagyánszki M. Region-dependent effects of diabetes and insulin-replacement on neuronal nitric oxide synthase- and heme oxygenase-immunoreactive submucous neurons. World J Gastroenterol 2017; 23(41): 7359-7368 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i41/7359.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i41.7359 |
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