Publication Name	World Journal of Gastroenterology
Manuscript ID	35070
Country	Hungary

Received	2017-06-15 10:10
Peer-Review Started	2017-06-16 07:07
To Make the First Decision	2017-07-13 05:40
Return for Revision	2017-07-13 08:29
Revised	2017-07-26 20:08
Second Decision	2017-08-21 07:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-08-25 14:29
Articles in Press	2017-08-25 14:29
Publication Fee Transferred	2017-09-29 05:32
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-10-30 03:15
Publish the Manuscript Online	2017-11-05 00:48

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, and build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Region-dependent effects of diabetes and insulin-replacement on neuronal nitric oxide synthase- and heme oxygenase-immunoreactive submucous neurons
Manuscript Source	Unsolicited Manuscript
All Author List	Nikolett Bódi, Zita Szalai, Lalitha Chandrakumar and Mária Bagyánszki
ORCID	Author(s) ORCID Number Nikolett Bódi http://orcid.org/0000-0002-9774-1387 Zita Szalai http://orcid.org/0000-0002-8722-0211 Lalitha Chandrakumar http://orcid.org/0000-0003-3674-5306 Mária Bagyánszki http://orcid.org/0000-0003-3533-9461
Funding Agency and Grant Number	Funding Agency Grant Number Hungarian Scientific Research Fund, OTKA grant PD 108309 the János Bolyai Research Scholarship of the Hungarian Academy of Sciences the Stipendium Hungaricum Scholarship 2015-SH-500041
Corresponding Author	Mária Bagyánszki, PhD, Associate Professor, Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged H-6726, Hungary. bmarcsi@bio.u-szeged.hu
Key Words	Submucous neurons; Nitrergic neurons; Heme oxygenase 1; Heme oxygenase 2; Gut region-specificity; Diabetes; Insulin
Core Tip	Our present findings demonstrate for the first time the segment–specific alterations of the proportion of nitrergic, heme oxygenase (HO)1-immunoreactive (IR) and HO2-IR neurons in the submucous plexus of control, diabetic and insulin-treated diabetic rats. Our results suggest that duodenal nitrergic neurons are not affected, but ileal and colonic ones are induced to change their neurochemical character in diabetes and insulin replacement. The colonic ganglia are abundant in HO-IR neurons in both controls and diabetics, whereas insulin treatment decreases their proportion. In contrast to the colon, the low amount of HO-IR ileal neurons was increased by insulin-treatment.
Publish Date	2017-11-05 00:48
Citation	Bódi N, Szalai Z, Chandrakumar L, Bagyánszki M. Region-dependent effects of diabetes and insulin-replacement on neuronal nitric oxide synthase- and heme oxygenase-immunoreactive submucous neurons. World J Gastroenterol 2017; 23(41): 7359-7368
URL	http://www.wjgnet.com/1007-9327/full/v23/i41/7359.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i41.7359

Full Article (PDF)	WJG-23-7359.pdf
Full Article (Word)	WJG-23-7359.doc
Manuscript File	35070-Review.doc
Answering Reviewers	35070-Answering reviewers.pdf
Audio Core Tip	35070-Audio core tip.mp3
Biostatistics Review Certificate	35070-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	35070-Conflict-of-interest statement.pdf
Copyright License Agreement	35070-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	35070-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	35070-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	35070-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	35070-Language certificate.PDF
Peer-review Report	35070-Peer-review(s).pdf
Scientific Misconduct Check	35070-Scientific misconduct check.pdf
Scientific Editor Work List	35070-Scientific editor work list.pdf