Publication Name	World Journal of Gastroenterology
Manuscript ID	3510
Country	France

Received	2013-05-03 11:22
Peer-Review Started	2013-05-03 20:54
To Make the First Decision	2013-05-23 17:17
Return for Revision	2013-05-24 11:02
Revised	2013-06-18 00:15
Second Decision	2013-07-05 11:57
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-07-05 13:07
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-11-29 23:36
Typeset the Manuscript	2013-12-18 15:34
Publish the Manuscript Online	2014-01-14 20:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Smoothelin, a new marker to determine the origin of liver fibrogenic cells
Manuscript Source	Invited Manuscript
All Author List	Sébastien Lepreux, Christelle Guyot, Fabrice Billet, Chantal Combe, Charles Balabaud, Paulette Bioulac-Sage and Alexis Desmoulière
Funding Agency and Grant Number	Funding Agency Grant Number French Ministry of Research (in part)
Corresponding Author	Alexis Desmoulière, PhD, Faculté de Pharmacie, Université de Limoges, 2 rue du Docteur Marcland, EA 6309, F-87025 Limoges, France. alexis.desmouliere@unilim.fr
Key Words	Smooth muscle cells; Myofibroblasts; -smooth muscle actin; Smoothelin; Fibrosis/cirrhosis; Hepatocellular carcinoma
Core Tip	In fibrotic conditions, it has been suggested that smooth muscle cells can acquire a myofibroblastic phenotype. To explore this hypothesis, we studied the expression of smoothelin, a specific marker of end-stage differentiation of smooth muscle cells, in cutaneous and hepatic fibrotic conditions, using immunohistochemistry and confocal microscopy. We showed that during advanced liver fibrosis, a subpopulation of ?-smooth muscle actin-expressing myofibroblasts also express smoothelin and thus may be derived from vascular smooth muscle cells. This finding, which illustrates the different potential cellular origins of myofibroblasts involved in liver fibrogenesis, may represent an interesting tool to distinguish advanced stages of cirrhosis.
Publish Date	2014-01-14 20:11
Citation	Lepreux S, Guyot C, Billet F, Combe C, Balabaud C, Bioulac-Sage P, Desmoulière A. Smoothelin, a new marker to determine the origin of liver fibrogenic cells. World J Gastroenterol 2013; 19(48): 9343-9350
URL	http://www.wjgnet.com/1007-9327/full/v19/i48/9343.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i48.9343

Full Article (PDF)	WJG-19-9343.pdf
Manuscript File	3510-Review.doc
Answering Reviewers	3510-Answering reviewers.pdf
Copyright License Agreement	3510-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	3510-Language certificate.pdf
Peer-review Report	3510-Peer reviews.pdf
Scientific Editor Work List	3510-Scientific editor work list.doc