Publication Name	World Journal of Gastroenterology
Manuscript ID	35229
Country	China

Received	2017-07-26 01:08
Peer-Review Started	2017-07-26 12:51
To Make the First Decision	2017-08-10 00:28
Return for Revision	2017-08-14 13:32
Revised	2017-09-09 05:26
Second Decision	2017-09-15 00:07
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-09-19 20:56
Articles in Press	2017-09-19 20:56
Publication Fee Transferred	2017-10-02 14:49
Edit the Manuscript by Language Editor	2017-10-16 13:26
Typeset the Manuscript	2017-10-31 03:50
Publish the Manuscript Online	2017-11-05 00:48

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Efficacy of postoperative adjuvant transcatheter arterial chemoembolization in hepatocellular carcinoma patients with microvascular invasion
Manuscript Source	Unsolicited Manuscript
All Author List	Jia-Zhou Ye, Jun-Ze Chen, Zi-Hui Li, Tao Bai, Jie Chen, Shao-Liang Zhu, Le-Qun Li and Fei-Xiang Wu
ORCID	Author(s) ORCID Number Jia-Zhou Ye http://orcid.org/0000-0003-4131-8130 Jun-Ze Chen http://orcid.org/0000-0001-7027-2608 Zi-Hui Li http://orcid.org/0000-0002-6470-7780 Tao Bai http://orcid.org/0000-0002-5969-8920 Jie Chen http://orcid.org/0000-0001-8909-6974 Shao-Liang Zhu http://orcid.org/0000-0002-7645-5330 Le-Qun Li http://orcid.org/0000-0003-2553-7720 Fei-Xiang Wu http://orcid.org/0000-0002-8880-7460
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Guangxi 2012GXNSFAA053162 Key project of Guangxi Health and Family Planning Commission, China S201513 Key Project of Guangxi Science and Technology Department, China Gui Ke AB16380242
Corresponding Author	Fei-Xiang Wu, MD, Professor, Department of Hepatobiliary Surgery, Affiliated Tumor Hospital of Guangxi Medical University, He Di Road No. 71, Nanning 530021, Guangxi Zhuang Autonomous Region, China. wufeixiang@gxmu.edu.cn
Key Words	Hepatocellular carcinoma; Microvascular invasion; Postoperative adjuvant transcatheter arterial chemoembolization; Recurrence-free survival; Overall survival
Core Tip	Microvascular invasion (MVI) is an independent risk factor attributed to frequent tumor recurrence in Barcelona Clinic Liver Cancer (BCLC) early- and intermediate-stage hepatocellular carcinoma (HCC) patients. Postoperative adjuvant transcatheter arterial chemoembolization (PA-TACE) has been confirmed to be effective in suppressing early recurrence and delaying the progression of recurrent tumors, thereby improving the overall survival (OS) in HCC patients with macrovascular invasion. However, whether PA-TACE could provide the survival benefit to HCC patients with MVI remains unclear. The present study showed that PA-TACE is an effective method that can safely suppress the recurrence and improve the survival of BCLC early- and intermediate-stage HCC patients with MVI. However, it failed to provide obvious OS or recurrence-free survival benefits to patients without MVI.
Publish Date	2017-11-05 00:48
Citation	Ye JZ, Chen JZ, Li ZH, Bai T, Chen J, Zhu SL, Li LQ, Wu FX. Efficacy of postoperative adjuvant transcatheter arterial chemoembolization in hepatocellular carcinoma patients with microvascular invasion. World J Gastroenterol 2017; 23(41): 7415-7424
URL	http://www.wjgnet.com/1007-9327/full/v23/i41/7415.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i41.7415

Full Article (PDF)	WJG-23-7415.pdf
Full Article (Word)	WJG-23-7415.doc
Manuscript File	35229-Review.doc
Answering Reviewers	35229-Answering reviewers.pdf
Audio Core Tip	35229-Audio core tip.mp3
Biostatistics Review Certificate	35229-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	35229-Conflict-of-interest statement.pdf
Copyright License Agreement	35229-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	35229-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	35229-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	35229-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	35229-Language certificate.pdf
Supplementary Material	35229-Supplementary-Material.tif
Peer-review Report	35229-Peer-review(s).pdf
Scientific Misconduct Check	35229-Scientific misconduct check.pdf
Scientific Editor Work List	35229-Scientific editor work list.pdf