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10/21/2017 7:10:38 AM | Browse: 1171 | Download: 1350
Publication Name World Journal of Gastroenterology
Manuscript ID 35253
Country China
Received
2017-07-24 03:18
Peer-Review Started
2017-07-24 12:06
To Make the First Decision
2017-08-15 03:48
Return for Revision
2017-08-21 00:39
Revised
2017-08-27 13:03
Second Decision
2017-09-06 23:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-09-13 03:00
Articles in Press
2017-09-13 03:00
Publication Fee Transferred
2017-09-21 03:05
Edit the Manuscript by Language Editor
2017-09-26 18:21
Typeset the Manuscript
2017-10-12 03:12
Publish the Manuscript Online
2017-10-21 07:10
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Integrative & Complementary Medicine
Manuscript Type Basic Study
Article Title Optimal timing for the oral administration of Da-Cheng-Qi decoction based on the pharmacokinetic and pharmacodynamic targeting of the pancreas in rats with acute pancreatitis
Manuscript Source Unsolicited Manuscript
All Author List Yu-Mei Zhang, Lin Zhu, Xian-Lin Zhao, Huan Chen, Hong-Xin Kang, Jian-Lei Zhao, Mei-Hua Wan, Juan Li, Lv Zhu and Wen-Fu Tang
ORCID
Author(s) ORCID Number
Yu-Mei Zhang http://orcid.org/0000-0001-9802-776X
Lin Zhu http://orcid.org/0000-0001-9126-5722
Xian-Lin Zhao http://orcid.org/0000-0002-2110-2941
Huan Chen http://orcid.org/0000-0002-4763-6730
Hong-Xin Kang http://orcid.org/0000-0001-8212-0134
Jian-Lei Zhao http://orcid.org/0000-0001-8636-593X
Mei-Hua Wan http://orcid.org/0000-0002-1237-9455
Juan Li http://orcid.org/0000-0002-5775-9355
Lv Zhu http://orcid.org/0000-0002-4302-3339
Wen-Fu Tang http://orcid.org/0000-0001-9294-6634
Funding Agency and Grant Number
Funding Agency Grant Number
the National Natural Science Foundation of China 81374042
the National Natural Science Foundation of China 81370091
the National Natural Science Foundation of China 81603480
Corresponding Author Wen-Fu Tang, PhD, Professor, Department of Integrative Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, Sichuan Province, China. tangwf@scu.edu.cn
Key Words Da-Cheng-Qi decoction; Acute pancreatitis; Pharmacokinetics; Oral dosing time; Pharmacodynamics
Core Tip Our study group had raised the hypothesis of tissue pharmacology of an herbal recipe, which assumed the effect of an herb formula is related to its target tissue distribution or concentration of effective components in target tissues. This study was then designed to screen the optimal oral dosing time of Da-Cheng-Qi decoction (DCQD) in rats with acute pancreatitis based on the pharmacokinetics of the main absorbed components and the pharmacodynamics of DCQD targeting of the pancreas.
Publish Date 2017-10-21 07:10
Citation Zhang YM, Zhu L, Zhao XL, Chen H, Kang HX, Zhao JL, Wan MH, Li J, Zhu L, Tang WF. Optimal timing for the oral administration of Da-Cheng-Qi decoction based on the pharmacokinetic and pharmacodynamic targeting of the pancreas in rats with acute pancreatitis. World J Gastroenterol 2017; 23(39): 7098-7109
URL http://www.wjgnet.com/1007-9327/full/v23/i39/7098.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i39.7098
Full Article (PDF) WJG-23-7098.pdf
Full Article (Word) WJG-23-7098.doc
Manuscript File 35253-Review.docx
Answering Reviewers 35253-Answering reviewers.pdf
Audio Core Tip 35253-Audio core tip.mp3
Biostatistics Review Certificate 35253-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 35253-Conflict-of-interest statement.pdf
Copyright License Agreement 35253-Copyright-Assignment-revision.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 35253-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 35253-Institutional animal care and use committee statemen.pdf
Institutional Review Board Approval Form or Document 35253-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 35253-Language certificate.pdf
Supplementary Material 35253-Supplementary-Material-revision.xls
Peer-review Report 35253-Peer-review(s).pdf
Scientific Misconduct Check 35253-Scientific misconduct check.pdf
Scientific Editor Work List 35253-Scientific editor work list.pdf