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11/12/2017 6:39:43 AM | Browse: 1593 | Download: 3030
Publication Name World Journal of Gastroenterology
Manuscript ID 35258
Country China
Received
2017-07-20 01:38
Peer-Review Started
2017-07-20 07:09
First Decision by Editorial Office Director
2017-08-15 02:52
Return for Revision
2017-08-21 00:36
Revised
2017-09-08 16:04
Publication Fee Transferred
2017-09-21 05:14
Second Decision by Editor
2017-09-15 03:51
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2017-09-19 20:57
Articles in Press
2017-09-19 20:57
Edit the Manuscript by Language Editor
2017-09-30 20:27
Typeset the Manuscript
2017-11-02 10:09
Publish the Manuscript Online
2017-11-12 06:39
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Effects of Hemp seed soft capsule on colonic ion transport in rats
Manuscript Source Unsolicited Manuscript
All Author List Xiao-Fang Lu, Meng-Di Jia, Sheng-Sheng Zhang and Lu-Qing Zhao
ORCID
Author(s) ORCID Number
Xiao-Fang Lu http://orcid.org/0000-0002-1837-1091
Meng-Di Jia http://orcid.org/0000-0001-7784-8067
Sheng-Sheng Zhang http://orcid.org/0000-0003-0457-1727
Lu-Qing Zhao http://orcid.org/0000-0003-1986-3511
Funding Agency and Grant Number
Funding Agency Grant Number
Clinical Medicine Development Project of Beijing Municipal Administration of Hospitals ZYLX201411
Corresponding Author Sheng-Sheng Zhang, MD, Doctor, Doctor, Digestive Disease Center, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, 23 Meishuguanhou Street, Beijing 100010, China. zhss2000@163.com
Key Words Hemp seed soft capsule; Constipation; Ion transport; Cl−; HCO3−
Core Tip In the study, we estabished a constipation model using the application of loperamide and found that Hemp seed soft capsule could improve the symptom of constipation. Further, it was found that the effect of Hemp seed soft capsule might be achieved by increasing the colonic secretion, mediated via the combined action of cAMP- dependent and Ca2+- dependent Cl− channels, NKCC, Na+-HCO3− cotransporter or Cl−/HCO3− exchanger. However, the submucosal neurons seemed not to play a key role in the process.
Publish Date 2017-11-12 06:39
Citation Lu XF, Jia MD, Zhang SS, Zhao LQ. Effects of Hemp seed soft capsule on colonic ion transport in rats. World J Gastroenterol 2017; 23(42): 7563-7571
URL http://www.wjgnet.com/1007-9327/full/v23/i42/7563.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i42.7563
Full Article (PDF) WJG-23-7563.pdf
Full Article (Word) WJG-23-7563.doc