Publication Name	World Journal of Gastroenterology
Manuscript ID	35337
Country	China

Received	2017-07-17 00:53
Peer-Review Started	2017-07-18 05:06
To Make the First Decision	2017-08-30 02:55
Return for Revision	2017-08-31 06:26
Revised	2017-09-14 08:47
Second Decision	2017-09-25 07:24
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-09-26 01:45
Articles in Press	2017-09-26 01:45
Publication Fee Transferred	2017-09-29 09:32
Edit the Manuscript by Language Editor	2017-10-11 19:52
Typeset the Manuscript	2017-11-06 04:37
Publish the Manuscript Online	2017-11-12 06:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Diversity of bacterial lactase genes in intestinal contents of mice with antibiotics-induced diarrhea
Manuscript Source	Unsolicited Manuscript
All Author List	Cheng-Xing Long, Lu He, Yan-Fang Guo, Ya-Wei Liu, Nen-Qun Xiao and Zhou-Jin Tan
ORCID	Author(s) ORCID Number Cheng-Xing Long http://orcid.org/0000-0002-7294-9472 Lu He http://orcid.org/0000-0003-3177-1214 Yan-Fang Guo http://orcid.org/0000-0002-2408-1672 Ya-Wei Liu http://orcid.org/0000-0002-4511-2837 Nen-Qun Xiao http://orcid.org/0000-0002-6036-0046 Zhou-Jin Tan http://orcid.org/0000-0003-3193-073x
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81573951
Corresponding Author	Zhou-Jin Tan, PhD, Professor, School of Medicine, Hunan University of Chinese Medicine, Bachelor Road, Changsha 410208, Hunan Province, China. tanzhjin@sohu.com
Key Words	Antibiotics-induced diarrhea; Lactase genes; Gene diversity; Intestinal bacteria; High-throughput sequencing
Core Tip	The mechanism of antibiotics-induced diarrhea has been studied in a wide range of diverse microbes, but less on functional enzymes. The current study aimed to determine the mechanism of lactase activity from genetic diversity and provide a basis for antibiotics-induced diarrhea. Alpha/Beta diversity analysis showed that there were significant differences between the control mice and model mice in types of lactase genes expressed and their activities. Following the antibiotics-induced diarrhea symptoms, the intestinal lactase genes changed, the number of strains was reduced and the abundance decreased, indicating changes in community structure and decreased diversity of lactase genes.
Publish Date	2017-11-12 06:39
Citation	Long CX, He L, Guo YF, Liu YW, Xiao NQ, Tan ZJ. Diversity of bacterial lactase genes in intestinal contents of mice with antibiotics-induced diarrhea. World J Gastroenterol 2017; 23(42): 7584-7593
URL	http://www.wjgnet.com/1007-9327/full/v23/i42/7584.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i42.7584

Full Article (PDF)	WJG-23-7584.pdf
Full Article (Word)	WJG-23-7584.doc
Manuscript File	35337-Review.doc
Answering Reviewers	35337-Answering reviewers.pdf
Audio Core Tip	35337-Audio core tip.mp3
Biostatistics Review Certificate	35337-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	35337-Conflict-of-interest statement.pdf
Copyright License Agreement	35337-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	35337-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	35337-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	35337-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	35337-Language certificate.pdf
Supplementary Material	35337-Supplementary-Material-revision_3900.pdf
Peer-review Report	35337-Peer-review(s).pdf
Scientific Misconduct Check	35337-Scientific misconduct check.pdf
Scientific Editor Work List	35337-Scientific editor work list.pdf