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11/12/2017 6:39:43 AM | Browse: 878 | Download: 1602
Publication Name World Journal of Gastroenterology
Manuscript ID 35337
Country/Territory China
Received
2017-07-17 00:53
Peer-Review Started
2017-07-18 05:06
To Make the First Decision
2017-08-30 02:55
Return for Revision
2017-08-31 06:26
Revised
2017-09-14 08:47
Second Decision
2017-09-25 07:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-09-26 01:45
Articles in Press
2017-09-26 01:45
Publication Fee Transferred
2017-09-29 09:32
Edit the Manuscript by Language Editor
2017-10-11 19:52
Typeset the Manuscript
2017-11-06 04:37
Publish the Manuscript Online
2017-11-12 06:39
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Diversity of bacterial lactase genes in intestinal contents of mice with antibiotics-induced diarrhea
Manuscript Source Unsolicited Manuscript
All Author List Cheng-Xing Long, Lu He, Yan-Fang Guo, Ya-Wei Liu, Nen-Qun Xiao and Zhou-Jin Tan
ORCID
Author(s) ORCID Number
Cheng-Xing Long http://orcid.org/0000-0002-7294-9472
Lu He http://orcid.org/0000-0003-3177-1214
Yan-Fang Guo http://orcid.org/0000-0002-2408-1672
Ya-Wei Liu http://orcid.org/0000-0002-4511-2837
Nen-Qun Xiao http://orcid.org/0000-0002-6036-0046
Zhou-Jin Tan http://orcid.org/0000-0003-3193-073x
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81573951
Corresponding Author Zhou-Jin Tan, PhD, Professor, School of Medicine, Hunan University of Chinese Medicine, Bachelor Road, Changsha 410208, Hunan Province, China. tanzhjin@sohu.com
Key Words Antibiotics-induced diarrhea; Lactase genes; Gene diversity; Intestinal bacteria; High-throughput sequencing
Core Tip The mechanism of antibiotics-induced diarrhea has been studied in a wide range of diverse microbes, but less on functional enzymes. The current study aimed to determine the mechanism of lactase activity from genetic diversity and provide a basis for antibiotics-induced diarrhea. Alpha/Beta diversity analysis showed that there were significant differences between the control mice and model mice in types of lactase genes expressed and their activities. Following the antibiotics-induced diarrhea symptoms, the intestinal lactase genes changed, the number of strains was reduced and the abundance decreased, indicating changes in community structure and decreased diversity of lactase genes.
Publish Date 2017-11-12 06:39
Citation Long CX, He L, Guo YF, Liu YW, Xiao NQ, Tan ZJ. Diversity of bacterial lactase genes in intestinal contents of mice with antibiotics-induced diarrhea. World J Gastroenterol 2017; 23(42): 7584-7593
URL http://www.wjgnet.com/1007-9327/full/v23/i42/7584.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i42.7584
Full Article (PDF) WJG-23-7584.pdf
Full Article (Word) WJG-23-7584.doc
Manuscript File 35337-Review.doc
Answering Reviewers 35337-Answering reviewers.pdf
Audio Core Tip 35337-Audio core tip.mp3
Biostatistics Review Certificate 35337-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 35337-Conflict-of-interest statement.pdf
Copyright License Agreement 35337-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 35337-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 35337-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 35337-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 35337-Language certificate.pdf
Supplementary Material 35337-Supplementary-Material-revision_3900.pdf
Peer-review Report 35337-Peer-review(s).pdf
Scientific Misconduct Check 35337-Scientific misconduct check.pdf
Scientific Editor Work List 35337-Scientific editor work list.pdf