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Articles Published Processes
11/12/2017 6:39:43 AM | Browse: 1145 | Download: 2807
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Received |
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2017-07-17 00:53 |
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Peer-Review Started |
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2017-07-18 05:06 |
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First Decision by Editorial Office Director |
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2017-08-30 02:27 |
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Return for Revision |
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2017-08-31 06:26 |
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Revised |
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2017-09-14 08:47 |
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Publication Fee Transferred |
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2017-09-29 09:32 |
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Second Decision by Editor |
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2017-09-25 07:24 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2017-09-26 01:45 |
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Articles in Press |
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2017-09-26 01:45 |
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Edit the Manuscript by Language Editor |
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2017-10-11 19:52 |
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Typeset the Manuscript |
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2017-11-06 04:37 |
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Publish the Manuscript Online |
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2017-11-12 06:39 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Diversity of bacterial lactase genes in intestinal contents of mice with antibiotics-induced diarrhea
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Cheng-Xing Long, Lu He, Yan-Fang Guo, Ya-Wei Liu, Nen-Qun Xiao and Zhou-Jin Tan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81573951 |
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| Corresponding Author |
Zhou-Jin Tan, PhD, Professor, School of Medicine, Hunan University of Chinese Medicine, Bachelor Road, Changsha 410208, Hunan Province, China. tanzhjin@sohu.com |
| Key Words |
Antibiotics-induced diarrhea; Lactase genes; Gene diversity; Intestinal bacteria; High-throughput sequencing |
| Core Tip |
The mechanism of antibiotics-induced diarrhea has been studied in a wide range of diverse microbes, but less on functional enzymes. The current study aimed to determine the mechanism of lactase activity from genetic diversity and provide a basis for antibiotics-induced diarrhea. Alpha/Beta diversity analysis showed that there were significant differences between the control mice and model mice in types of lactase genes expressed and their activities. Following the antibiotics-induced diarrhea symptoms, the intestinal lactase genes changed, the number of strains was reduced and the abundance decreased, indicating changes in community structure and decreased diversity of lactase genes. |
| Publish Date |
2017-11-12 06:39 |
| Citation |
Long CX, He L, Guo YF, Liu YW, Xiao NQ, Tan ZJ. Diversity of bacterial lactase genes in intestinal contents of mice with antibiotics-induced diarrhea. World J Gastroenterol 2017; 23(42): 7584-7593 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i42/7584.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i42.7584 |
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