Publication Name	World Journal of Gastroenterology
Manuscript ID	3541
Country	China

Received	2013-05-05 15:20
Peer-Review Started	2013-05-06 09:04
To Make the First Decision	2013-05-23 17:15
Return for Revision	2013-06-02 20:21
Revised	2013-06-28 01:38
Second Decision	2013-07-17 18:19
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-07-18 13:35
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-08-22 16:14
Publish the Manuscript Online	2013-09-09 09:30

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Xiaotan Tongfu granules contribute to the prevention of stress ulcers
Manuscript Source	Invited Manuscript
All Author List	Bing Yan, Jun Shi, Li-Juan Xiu, Xuan Liu, Yu-Qi Zhou, Shou-Han Feng, Can Lv, Xiu-Xia Yuan, Yin-Cheng Zhang, Yong-Jin Li, Pin-Kang Wei and Zhi-Feng Qin
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of China 2010Z131 Excellent Master Training Fund of the Second Military Medical University
Corresponding Author	Dr. Zhi-Feng Qin, Department of Traditional Chinese Medicine, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China. yanbing3741@gmail.com
Key Words	Stress ulcer; Xiaotan Tongfu granule; Inflammation; Heat shock protein 70; Proliferation and apoptosis; Gastric emptying rate
Core Tip	Although the underlying mechanism of stress ulcers is commonly believed to depend on the balance between known aggressive factors and mucosal defense mechanisms, most clinical strategies still aim to inhibit gastric acid. In this study, we demonstrated that the Xiaotan Tongfu granule was similar to ranitidine treatment in reducing gastric lesions in a cold-restraint stress model. The underlying mechanisms may include acceleration of the gastric emptying rate, inhibition of local inflammation, promotion of cell proliferation and suppression of apoptosis. Our study indicated that multiple manipulations of the factors involved in inducing stress ulcers could be as effective as simple acid inhibition.
Publish Date	2013-09-09 09:30
Citation	Yan B, Shi J, Xiu LJ, Liu X, Zhou YQ, Feng SH, Lv C, Yuan XX, Zhang YC, Li YJ, Wei PK, Qin ZF. Xiaotan Tongfu granules contribute to the prevention of stress ulcers. World J Gastroenterol 2013; 19(33): 5473-5484
URL	http://www.wjgnet.com/1007-9327/full/v19/i33/5473.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i33.5473

Full Article (PDF)	WJG-19-5473.pdf
Manuscript File	3541-Review.doc
Answering Reviewers	3541-Answering reviewers.pdf
Copyright License Agreement	3541-Copyright assignment.doc
Non-Native Speakers of English Editing Certificate	3541-Language certificate.pdf
Peer-review Report	3541-Peer review(s).pdf
Scientific Editor Work List	3541-Scientific editor work list.doc