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Articles Published Processes
10/29/2017 6:01:43 AM | Browse: 1360 | Download: 1905
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Received |
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2017-08-19 05:47 |
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Peer-Review Started |
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2017-08-19 06:21 |
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To Make the First Decision |
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2017-09-06 03:35 |
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Return for Revision |
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2017-09-08 01:00 |
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Revised |
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2017-09-22 08:32 |
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Second Decision |
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2017-09-28 04:04 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-09-28 18:02 |
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Articles in Press |
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2017-09-28 18:02 |
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Publication Fee Transferred |
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2017-09-30 10:16 |
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Edit the Manuscript by Language Editor |
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2017-10-14 21:14 |
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Typeset the Manuscript |
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2017-10-23 03:09 |
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Publish the Manuscript Online |
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2017-10-29 06:01 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Dachaihu decoction ameliorates pancreatic fibrosis by inhibiting macrophage infiltration in chronic pancreatitis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Fang Duan, Xiao-Fan Xu, Lin-Jia Zhu, Fang Liu, Xiao-Qin Zhang, Nan Wu, Jian-Wei Fan, Jia-Qi Xin and Hong Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Natural Science Foundation of China |
No.81673816 |
| Key Basic Research Project of Shaanxi Province |
No.2017ZDJC-14 |
| Key Research Program of Natural Science of Shaanxi Education Department |
No.15JS027 |
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| Corresponding Author |
Hong Zhang, PhD, Professor, Department of Pathophysiology, Shaanxi University of Chinese Medicine, Century Avenue, Xianyang 712046, Shaanxi Province, China. zhangh1227@163.com |
| Key Words |
Dachaihu decoction; Pancreatic fibrosis; Macrophages; Interleukin-6 |
| Core Tip |
Macrophages, important inflammatory cells, can also promote fibrogenesis by interfering with the synthesis and degradation of the extracellular matrix, as confirmed in both liver fibrosis and renal fibrosis models. Our study suggested that macrophages also play an important role in the development of pancreatic fibrosis. We found that macrophages are an important source of IL-6, which is involved in the progression of CP. Dachaihu decoction (DCHD), a traditional Chinese medicinal formula, effectively improves the clinical symptoms of CP patients, but the underlying mechanism remains unclear. We found that DCHD ameliorates pancreatic fibrosis by inhibiting macrophage infiltration and inflammatory factor secretion. |
| Publish Date |
2017-10-29 06:01 |
| Citation |
Duan LF, Xu XF, Zhu LJ, Liu F, Zhang XQ, Wu N, Fan JW, Xin JQ, Zhang H. Dachaihu decoction ameliorates pancreatic fibrosis by inhibiting macrophage infiltration in chronic pancreatitis. World J Gastroenterol 2017; 23(40): 7242-7252 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i40/7242.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i40.7242 |
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