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12/27/2017 11:08:07 AM | Browse: 307 | Download: 192
Publication Name World Journal of Gastroenterology
Manuscript ID 35483
Country of Manuscript Source China
Received
2017-07-25 14:16
Peer-Review Started
2017-07-25 21:17
To Make the First Decision
2017-09-15 01:31
Return for Revision
2017-09-17 18:50
Revised
2017-09-29 14:32
Second Decision
2017-11-21 10:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-11-21 18:55
Articles in Press
2017-11-21 18:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
2017-12-04 01:25
Typeset the Manuscript
2017-12-21 03:51
Publish the Manuscript Online
2017-12-27 11:08
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Oncology
Manuscript Type Basic Study
Article Title Astragaloside IV inhibits pathological functions of gastric cancer-associated fibroblasts
Manuscript Source Unsolicited Manuscript
All Author List Zhen-Fei Wang, Da-Guang Ma, Zhe Zhu, Yong-Ping Mu, Yong-Yan Yang, Li Feng, Hao Yang, Jun-Qing Liang, Yong-Yan Liu, Li Liu and Hai-Wen Lu
ORCID
Author(s) ORCID Number
Zhen-Fei Wang http://orcid.org/0000-0002-1541-8413
Da-Guang Ma http://orcid.org/0000-0003-0170-1768
Zhe Zhu http://orcid.org/0000-0002-6093-5241
Yong-Ping Mu http://orcid.org/0000-0002-4533-5563
Yong-Yan Yang http://orcid.org/0000-0002-9098-0991
Li Feng http://orcid.org/0000-0002-5157-056X
Hao Yang http://orcid.org/0000-0001-7347-9014
Jun-Qing Liang http://orcid.org/0000-0002-8799-5623
Yong-Yan Liu http://orcid.org/0000-0002-1683-6887
Li Liu http://orcid.org/0000-0002-2327-8932
Hai-Wen Lu http://orcid.org/0000-0003-1275-5411
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81760552
Program of the Inner Mongolia Natural Science Foundation 2016MS0824
Program of the Inner Mongolia Natural Science Foundation 2015MS0896
Program of “Keji Baiwan Gongcheng” of Inner Mongolia Medical University YKD2015KJBW008
Supporting Program for Outstanding Youth in Science and Technology of Inner Mongolia Autonomous Region NJYT-17-B30
Corresponding author Hai-Wen Lu, PhD, Professor, The Laboratory for Tumor Molecular Diagnosis, Affiliated People’s Hospital of Inner Mongolia Medical University, 42 Zhaowuda, Huhhot 010021, Inner Mongolia Autonomous Region, China. haiwen_l@yeah.net
Keywords Astragaloside IV; Gastric cancer-associated fibroblasts; Proliferation; Migration; Invasion; MicroRNA
Core Tip Most of the chemotherapeutic agents directly act on cancer cells. However, direct drug attacks on cancer cells have the drawbacks of accelerating cancer evolution, chemoresistance, recurrence and metastasis. Cancer-associated fibroblasts considerably contribute to cancer initiation and progression by providing nourishment and support for cancer cells. Blocking the pathological functions of cancer-associated fibroblasts can eliminate the conditions suitable for cancer cell survival and expansion, representing a novel effective anti-cancer strategy. Unfortunately, few effective drugs have been found against cancer-associated fibroblasts. Here, Astragaloside IV significantly inhibited the pathological functions of gastric cancer-associated fibroblast, suggesting its valuable therapeutic application for gastric carcinoma.
Publish Date 2017-12-27 11:08
Citation Wang ZF, Ma DG, Zhu Z, Mu YP, Yang YY, Feng L, Yang H, Liang JQ, Liu YY, Liu L, Lu HW. Astragaloside Ⅳ inhibits pathological functions of gastric cancer-associated fibroblasts. World J Gastroenterol 2017; 23(48): 8512-8525
Url http://www.wjgnet.com/1007-9327/full/v23/i48/8512.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i48.8512
Full Article (PDF) WJG-23-8512.pdf
Full Article (Word) WJG-23-8512.doc
Manuscript File 35483-Review.doc
Answering Reviewers 35483-Answering reviewers.pdf
Audio Core Tip 35483-Audio core tip.mp3
Biostatistics Review Certificate 35483-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 35483-Conflict-of-interest statement.pdf
Copyright License Agreement 35483-Copyright assignment.pdf
Data Sharing Statement 35483-Data-Sharing-Statement-revision.docx
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 35483-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 35483-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 35483-Language certificate.pdf
Scientific Research Process 35483-Scientific-Research-Process-revision.docx
Peer-review Report 35483-Peer-review(s).pdf
Scientific Misconduct Check 35483-Scientific misconduct check.pdf
Scientific Editor Work List 35483-Scientific editor work list.pdf