| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Astragaloside IV inhibits pathological functions of gastric cancer-associated fibroblasts
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhen-Fei Wang, Da-Guang Ma, Zhe Zhu, Yong-Ping Mu, Yong-Yan Yang, Li Feng, Hao Yang, Jun-Qing Liang, Yong-Yan Liu, Li Liu and Hai-Wen Lu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81760552 |
| Program of the Inner Mongolia Natural Science Foundation |
2016MS0824 |
| Program of the Inner Mongolia Natural Science Foundation |
2015MS0896 |
| Program of “Keji Baiwan Gongcheng” of Inner Mongolia Medical University |
YKD2015KJBW008 |
| Supporting Program for Outstanding Youth in Science and Technology of Inner Mongolia Autonomous Region |
NJYT-17-B30 |
|
| Corresponding Author |
Hai-Wen Lu, PhD, Professor, The Laboratory for Tumor Molecular Diagnosis, Affiliated People’s Hospital of Inner Mongolia Medical University, 42 Zhaowuda, Huhhot 010021, Inner Mongolia Autonomous Region, China. haiwen_l@yeah.net |
| Key Words |
Astragaloside IV; Gastric cancer-associated fibroblasts; Proliferation; Migration; Invasion; MicroRNA |
| Core Tip |
Most of the chemotherapeutic agents directly act on cancer cells. However, direct drug attacks on cancer cells have the drawbacks of accelerating cancer evolution, chemoresistance, recurrence and metastasis. Cancer-associated fibroblasts considerably contribute to cancer initiation and progression by providing nourishment and support for cancer cells. Blocking the pathological functions of cancer-associated fibroblasts can eliminate the conditions suitable for cancer cell survival and expansion, representing a novel effective anti-cancer strategy. Unfortunately, few effective drugs have been found against cancer-associated fibroblasts. Here, Astragaloside IV significantly inhibited the pathological functions of gastric cancer-associated fibroblast, suggesting its valuable therapeutic application for gastric carcinoma. |
| Publish Date |
2017-12-27 11:08 |
| Citation |
Wang ZF, Ma DG, Zhu Z, Mu YP, Yang YY, Feng L, Yang H, Liang JQ, Liu YY, Liu L, Lu HW. Astragaloside Ⅳ inhibits pathological functions of gastric cancer-associated fibroblasts. World J Gastroenterol 2017; 23(48): 8512-8525 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i48/8512.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i48.8512 |
