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Articles Published Processes
12/27/2017 11:08:07 AM | Browse: 1010 | Download: 1877
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Received |
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2017-07-28 08:41 |
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Peer-Review Started |
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2017-07-30 15:04 |
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To Make the First Decision |
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2017-08-30 03:13 |
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Return for Revision |
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2017-09-04 07:23 |
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Revised |
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2017-10-15 08:56 |
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Second Decision |
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2017-11-07 08:49 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-11-07 18:36 |
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Articles in Press |
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2017-11-07 18:36 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-12-14 10:38 |
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Publish the Manuscript Online |
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2017-12-27 11:08 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work noncommercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Basic Study |
| Article Title |
Influence of TBX21 T-1993C variant on autoimmune hepatitis development by Yin-Yang 1 binding
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Wei Suen, Hong-Yan Wu and Song Chen |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
30972595 |
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| Corresponding Author |
Song Chen, MD, Chief Doctor, Professor, Institute of Infectious Diseases, Southwest Hospital, Third Military Medical University, No.30 Gao Tan Yan Street,Sha Ping Ba District, Chongqing 400038, China. cs196@medmail.com.cn |
| Key Words |
TBX21; Single nucleotide polymorphism; YY1; T helper cells; B cells; Autoimmune hepatitis |
| Core Tip |
The -1993C allele in the TBX21 gene (encoding T-bet) promoter has been shown to associated with protection against autoimmune hepatitis type 1 (AIH-1), but the underlying mechanisms are unknown. We found that the TBX21-1993C allele created a strong Yin-Yang 1 (YY1)-binding site and decreased T-bet expression. Reduced T-bet and IFN-γ expression of circulating CD4+ T cells and B cells existed in the individuals carrying the -1993C allele compared with those without the -1993C allele and played a protective role in AIH-1 development. The repression of T-bet expression by high-affinity binding of YY1 to the -1993C allele may contribute to a decreased development of AIH-1 via the suppression of type 1 immunity. |
| Publish Date |
2017-12-27 11:08 |
| Citation |
Sun W, Wu HY, Chen S. Influence of TBX21 T-1993C variant on autoimmune hepatitis development by Yin-Yang 1 binding. World J Gastroenterol 2017; 23(48): 8500-8511 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i48/8500.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i48.8500 |
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