Publication Name	World Journal of Gastroenterology
Manuscript ID	3560
Country	Pakistan

Received	2013-05-07 07:43
Peer-Review Started	2013-05-07 10:02
To Make the First Decision	2013-06-09 10:10
Return for Revision	2013-06-19 20:41
Revised	2013-07-12 01:50
Second Decision	2013-12-03 20:59
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-12-04 06:26
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-04-03 04:51
Typeset the Manuscript	2014-04-29 11:07
Publish the Manuscript Online	2014-05-18 12:31

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Pathology
Manuscript Type	Autobiography
Article Title	Frequency of HER2/neu overexpression in adenocarcinoma of the gastrointestinal system
Manuscript Source	Invited Manuscript
All Author List	Sadaf Farzand, Tahir Siddique, Kanwal Saba and Mulazim Hussain Bukhari
Funding Agency and Grant Number
Corresponding Author	Mulazim Hussain Bukhari, Professor, Department of Pathobiology, King Edward Medical University, Nila Gumbad, Anarkali, Lahore 54000, Pakistan. mulazim.hussain@gmail.com
Key Words	HER2/neu; Immunohistochemistry; Adenocarcinoma; Gastrointestinal system
Core Tip	The role of HER2/neu was seen in 50 cases of gastrointestinal adenocarcinoma by immunohistochemistry. Overall, HER2/neu protein overexpression was found in 33 (66%) patients (P = 0.000), with 23 (69.6%) being colorectal carcinoma while the remaining 10 (30%) were gastric carcinoma. There was highly significant association between tumor grades and HER2/neu protein overexpression. HER2/neu protein was overexpressed in those adenocarcinomas showing a significant association between grade of tumor and HER2/neu protein overexpression. This discovery may improve treatment options for cases of gastric and colorectal carcinomas.
Publish Date	2014-05-18 12:31
Citation	Farzand S, Siddique T, Saba K, Bukhari MH. Frequency of HER2/neu overexpression in adenocarcinoma of gastrointestinal system. World J Gastroenterol 2014; 20(19): 5889-5896
URL	http://www.wjgnet.com/1007-9327/full/v20/i19/5889.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i19.5889

Full Article (PDF)	WJG-20-5889.pdf
Full Article (Word)	WJG-20-5889.doc
Manuscript File	3560-Review.doc
Answering Reviewers	3560-Answering reviewers.pdf
Biostatistics Review Certificate	Medical Bistatician Reports.pdf
Copyright License Agreement	3560-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	research ethical committe approval 001.jpg
Non-Native Speakers of English Editing Certificate	English review certificate.pdf
Peer-review Report	3560-Peer reviewer(s).pdf
Scientific Editor Work List	3560-Scientific editor work list.doc