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Articles Published Processes
12/4/2017 8:09:39 AM | Browse: 1245 | Download: 3061
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Received |
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2017-08-10 01:26 |
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Peer-Review Started |
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2017-08-10 02:47 |
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First Decision by Editorial Office Director |
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2017-09-12 16:56 |
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Return for Revision |
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2017-09-13 01:09 |
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Revised |
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2017-09-26 15:54 |
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Publication Fee Transferred |
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2017-10-31 11:08 |
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Second Decision by Editor |
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2017-10-10 01:03 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2017-10-26 18:17 |
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Articles in Press |
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2017-10-26 18:17 |
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Edit the Manuscript by Language Editor |
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2017-11-15 12:44 |
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Typeset the Manuscript |
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2017-11-25 07:10 |
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Publish the Manuscript Online |
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2017-12-04 08:09 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Down-regulation of miR-30a-3p/5p promotes esophageal squamous cell carcinoma cell proliferation by activating the Wnt signaling pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bo Qi, Yan Wang, Zhi-Jun Chen, Xiang-Nan Li, Yu Qi, Yang Yang, Guang-Hui Cui, Hai-Zhou Guo, Wei-Hao Li and Song Zhao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Youth Fund of the First Affiliated Hospital of Xinxiang Medical University (Type A) |
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| Corresponding Author |
Song Zhao, MSc, Academic Fellow, Department of Thoracic Surgery, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou 450052, Henan Province, China. zhaosong@zzu.edu.cn |
| Key Words |
miR-30a-3p/5p; Proliferation; Esophageal squamous cell carcinoma; Wnt signaling pathway; Wnt2; Fzd2 |
| Core Tip |
In this work, we found that low expression of miR-30a-3p/5p was closely associated with advanced esophageal squamous cell carcinoma (ESCC) progression and poor prognosis of patients with ESCC. Down-regulation of miR-30a-3p/5p suppressed ESCC cell proliferation both in vitro and in vivo. Furthermore, miR-30a-3p and miR-30a-5p could inhibit the activity of the Wnt signaling pathway by targeting the 3’ untranslated regions of Wnt2 and Fzd2, respectively. This study provided further evidence suggesting that miR-30a-3p/5p are diagnostic and prognostic biomarkers for ESCC, as miR-30a-3p/5p participate in the activation of the Wnt signaling pathway and subsequently, the regulation of ESCC cell proliferation. |
| Publish Date |
2017-12-04 08:09 |
| Citation |
Qi B, Wang Y, Chen ZJ, Li XN, Qi Y, Yang Y, Cui GH, Guo HZ, Li WH, Zhao S. Down-regulation of miR-30a-3p/5p promotes esophageal squamous cell carcinoma cell proliferation by activating the Wnt signaling pathway. World J Gastroenterol 2017; 23(45): 7965-7977
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| URL |
http://www.wjgnet.com/1007-9327/full/v23/i45/7965.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i45.7965 |
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