Publication Name	World Journal of Hepatology
Manuscript ID	35743
Country	Japan

Received	2017-08-07 03:46
Peer-Review Started	2017-08-07 09:14
To Make the First Decision	2017-09-13 01:00
Return for Revision	2017-09-13 02:34
Revised	2017-10-09 13:48
Second Decision	2017-10-23 08:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-10-30 20:10
Articles in Press	2017-10-30 20:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-11-14 01:28
Publish the Manuscript Online	2017-11-16 01:53

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Liver atrophy after percutaneous transhepatic portal embolization occurs in two histological phases: Hepatocellular atrophy followed by apoptosis
Manuscript Source	Invited Manuscript
All Author List	Yasuhito Iwao, Hidenori Ojima, Tatsushi Kobayashi, Yoji Kishi, Satoshi Nara, Minoru Esaki, Kazuaki Shimada, Nobuyoshi Hiraoka, Minoru Tanabe and Yae Kanai
ORCID	Author(s) ORCID Number Yasuhito Iwao http://orcid.org/0000-0001-6715-7553 Hidenori Ojima http://orcid.org/0000-0001-9154-246X Tatsushi Kobayashi http://orcid.org/0000-0002-7310-2097 Yoji Kishi http://orcid.org/0000-0001-8885-1210 Satoshi Nara http://orcid.org/0000-0002-3516-8765 Minoru Esaki http://orcid.org/0000-0002-9631-6178 Kazuaki Shimada http://orcid.org/0000-0002-0613-4953 Nobuyoshi Hiraoka http://orcid.org/0000-0003-4215-4385 Minoru Tanabe http://orcid.org/0000-0003-4875-1471 Yae Kanai http://orcid.org/0000-0002-7904-9506
Funding Agency and Grant Number
Corresponding Author	Hidenori Ojima, MD, PhD, Division of Molecular Pathology, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. hojima@ncc.go.jp
Key Words	Liver atrophy; Portal vein embolization; Autophagy; Apoptosis; Zonation; Lobule
Core Tip	Liver atrophy after percutaneous transhepatic portal embolization (PTPE) in time-independent human studies is associated with hepatocyte shrinkage and apoptosis. In this preliminary study, we performed pathological examinations of liver specimens from five pigs that had undergone PTPE in a time-dependent model of liver atrophy. Two distinct phases of liver atrophy were identified: A hepatocellular atrophic phase, which may relate to autophagy, and an apoptotic phase. Despite liver atrophy appearing to be mostly resolved 2 wk after embolization, the period after PTPE could beneficially be extended to 4 wk to ensure contralateral hypertrophy and to allow the completion of liver atrophy.
Publish Date	2017-11-16 01:53
Citation	Iwao Y, Ojima H, Kobayashi T, Kishi Y, Nara S, Esaki M, Shimada K, Hiraoka N, Tanabe M, Kanai Y. Liver atrophy after percutaneous transhepatic portal embolization occurs in two histological phases: Hepatocellular atrophy followed by apoptosis. World J Hepatol 2017; 9(32): 1227-1238
URL	http://www.wjgnet.com/1948-5182/full/v9/i32/1227.htm
DOI	http://dx.doi.org/10.4254/wjh.v9.i32.1227

Full Article (PDF)	WJH-9-1227.pdf
Full Article (Word)	WJH-9-1227.doc
Manuscript File	35743-Review.docx
Answering Reviewers	35743-Answering reviewers.pdf
Audio Core Tip	35743-Audio core tip.mp3
Biostatistics Review Certificate	35743-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	35743-Conflict-of-interest statement.pdf
Copyright License Agreement	35743-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	35743-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	35743-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	35743-Language certificate.pdf
Peer-review Report	35743-Peer-review(s).pdf
Scientific Editor Work List	35743-Scientific editor work list.pdf