Publication Name	World Journal of Critical Care Medicine
Manuscript ID	3575
Country	United States

Received	2013-05-07 09:01
Peer-Review Started	2013-05-07 12:04
To Make the First Decision	2013-06-09 10:09
Return for Revision	2013-06-19 20:08
Revised	2013-06-20 02:14
Second Decision	2013-08-13 11:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-08-13 13:46
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-09-10 10:50
Publish the Manuscript Online	2013-10-31 15:14

ISSN	2220-3141(online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Critical Care Medicine
Manuscript Type	Autobiography
Article Title	Pyruvate-fortified resuscitation stabilizes cardiac electrical activity and energy metabolism during hypovolemia
Manuscript Source	Invited Manuscript
All Author List	Hunaid A Gurji, Daniel W White, Besim Hoxha, Jie Sun, Albert H Olivencia-Yurvati and Robert T Mallet
Funding Agency and Grant Number	Funding Agency Grant Number United States Department of Defense W911NF0910086 Graduate School of Biomedical Sciences University of North Texas Health Science Center (to Gurji HA and White DW)
Corresponding Author	Robert T Mallet, PhD, Department of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107-2699, United States. robert.mallet@unthsc.edu
Key Words	Creatine kinase; Electrocardiogram; Hypovolemia; 8-Isoprostane; Phosphocreatine; Reactive oxygen species; Ringer’s lactate
Core Tip	In goats subjected to exsanguination-induced hypovolemia and tourniquet-imposed hindlimb ischemia-reperfusion, intravenous resuscitation with Ringer’s lactate produced marked electrocardiographic instability, lipid peroxidation and inactivation of the critical creatine kinase system, which supplies energy for membrane ion transport. In comparison with lactated Ringer’s, resuscitation enriched with the natural antioxidant and energy substrate pyruvate stabilized cardiac rhythm, prevented lipid peroxidation, preserved creatine kinase activity and augmented myocardial energy reserves. Importantly, these favorable effects persisted for at least 3.5 h after terminating pyruvate-enriched resuscitation. Thus, pyruvate-enriched resuscitation prevented creatine kinase inactivation by oxidative stress, thereby preventing cardiac rhythm disturbances after central hypovolemia.
Publish Date	2013-10-31 15:14
Citation	Gurji HA, White DW, Hoxha B, Sun J, Olivencia-Yurvati AH, Mallet RT. Pyruvate-fortified resuscitation stabilizes cardiac electrical activity and energy metabolism during hypovolemia. World J Crit Care Med 2013; 2(4): 56-64
URL	http://www.wjgnet.com/2220-3141/full/v2/i4/56.htm
DOI	http://dx.doi.org/10.5492/wjccm.v2.i4.56

Full Article (PDF)	WJCCM-2-56.pdf
Manuscript File	3575-Review.docx
Answering Reviewers	3575-Answering reviewers.pdf
Copyright License Agreement	3575-Copyright assignment.pdf
Peer-review Report	3575-Peer reviewer(s).pdf
Scientific Editor Work List	3575-Scientific editor work list.doc