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Articles Published Processes
10/29/2017 6:01:43 AM | Browse: 1116 | Download: 2105
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Received |
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2017-08-19 01:36 |
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Peer-Review Started |
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2017-08-19 05:55 |
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To Make the First Decision |
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2017-08-29 23:50 |
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Return for Revision |
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2017-09-01 05:46 |
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Revised |
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2017-09-10 16:17 |
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Second Decision |
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2017-09-13 01:25 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-09-19 20:44 |
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Articles in Press |
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2017-09-19 20:44 |
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Publication Fee Transferred |
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2017-09-21 15:00 |
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Edit the Manuscript by Language Editor |
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2017-10-11 14:02 |
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Typeset the Manuscript |
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2017-10-23 03:17 |
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Publish the Manuscript Online |
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2017-10-29 06:01 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Hypothermic machine perfusion with metformin-University of Wisconsin solution for ex vivo preservation of standard and marginal liver grafts in a rat model
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Chao Chai, Guo-Xin Dang, Hai-Qi He, Jian-Hua Shi, Hong-Ke Zhang, Rui-Tao Zhang, Bo Wang, Liang-Shuo Hu and Yi Lv |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Natural Science Foundation |
No. 81470896 |
| the Project of Development and Innovation Team of Ministry of Education |
No. IRT_16R57 |
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| Corresponding Author |
Liang-Shuo Hu, MD, Research Associate, Surgeon, Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi’an Jiaotong University, No.277 West Yan-ta Road, Xi’an 710061, Shaanxi Province, China. huliangshuo1983@hotmail.com |
| Key Words |
Metformin; AMP-activated protein kinase; Cold ischemia injury; Hypothermic machine perfusion; Liver Grafts |
| Core Tip |
Metformin can activate AMP-activated protein kinase pathway that could enhance the activity of endothelial nitric oxide synthase and finally increase the generation of nitric oxide, which plays an important role in the protection of liver sinusoidal endothelial cells. Hence, our study was designed to evaluate protective effect of University of Wisconsin storage solution with metformin for preserving standard and marginal criteria liver grafts of young and aged rats ex vivo by hypothermic machine perfusion (HMP). According to the results, HMP of extracorporeal circulation with metformin can play a significant protective role for liver grafts during cold ischemia, with significant effects especially for the aged-marginal donor. |
| Publish Date |
2017-10-29 06:01 |
| Citation |
Chai YC, Dang GX, He HQ, Shi JH, Zhang HK, Zhang RT, Wang B, Hu LS, Lv Y. Hypothermic machine perfusion with metformin-University of Wisconsin solution for ex vivo preservation of standard and marginal liver grafts in a rat model. World J Gastroenterol 2017; 23(40): 7221-7231 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i40/7221.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i40.7221 |
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