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Articles Published Processes
11/20/2017 4:03:35 AM | Browse: 1375 | Download: 2627
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Received |
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2017-08-15 01:44 |
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Peer-Review Started |
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2017-08-15 06:53 |
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First Decision by Editorial Office Director |
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2017-08-29 20:10 |
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Return for Revision |
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2017-09-04 07:53 |
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Revised |
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2017-09-27 13:38 |
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Publication Fee Transferred |
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2017-10-12 05:32 |
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Second Decision by Editor |
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2017-09-28 06:47 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2017-09-28 18:05 |
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Articles in Press |
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2017-09-28 18:05 |
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Edit the Manuscript by Language Editor |
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2017-10-30 21:10 |
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Typeset the Manuscript |
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2017-11-13 01:41 |
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Publish the Manuscript Online |
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2017-11-20 04:03 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Palmitate induces fat accumulation by activating C/EBPβ-mediated G0S2 expression in HepG2 cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Nai-Qian Zhao, Xiao-Yan Li, Li Wang, Zi-Ling Feng, Xi-Fen Li, Yan-Fang Wen and Jin-Xiang Han |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Shanxi Province |
2014011043-1 |
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| Corresponding Author |
Nai-Qian Zhao, MD, Chief Doctor, Department of Gerontology, the Second Hospital of Shanxi Medical University, 382 Wuyi Road, Taiyuan 030001, Shanxi Province, China. m18235150464@163.com |
| Key Words |
Obesity; Nonalcoholic fatty liver disease; Saturated fatty acid; G0/G1 switch gene 2; CCAAT/enhancer binding protein β; Adipogenesis; Lipolysis; Proliferator-activated receptor γ |
| Core Tip |
Obesity-associated nonalcoholic fatty liver disease is characterized by excessive deposition of fat in hepatocytes. The saturated free fatty acid palmitate, the concentration of which is often elevated in obesity, is a major contributor to an increase in intrahepatic triglyceride. G0/G1 switch gene 2 (G0S2) is a critical regulator of hepatic lipid accumulation. However, the role of G0S2 and its transcriptional regulation in palmitate-induced hepatic lipid accumulation is not clear. We found that palmitate can induce lipid accumulation in HepG2 cells by activating C/EBPβ-mediated G0S2 expression. |
| Publish Date |
2017-11-20 04:03 |
| Citation |
Zhao NQ, Li XY, Wang L, Feng ZL, Li XF, Wen YF, Han JX. Palmitate induces fat accumulation by activating C/EBPβ-mediated G0S2 expression in HepG2 cells. World J Gastroenterol 2017; 23(43): 7705-7715 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i43/7705.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i43.7705 |
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