Publication Name	World Journal of Gastroenterology
Manuscript ID	3593
Country	Italy

Received	2013-05-08 08:59
Peer-Review Started	2013-05-08 13:50
First Decision by Editorial Office Director
Return for Revision	2013-06-20 19:53
Revised	2013-07-16 01:08
Publication Fee Transferred
Second Decision by Editor	2013-08-19 12:25
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-08-20 00:08
Articles in Press
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-12-08 13:49
Publish the Manuscript Online	2013-12-18 10:00

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Genetics & Heredity
Manuscript Type	Autobiography
Article Title	Synergistic effect of interleukin-10-receptor variants in a case of early-onset ulcerative colitis
Manuscript Source	Invited Manuscript
All Author List	Martina Galatola, Erasmo Miele, Caterina Strisciuglio, Lorella Paparo, Daniela Rega, Paolo Delrio, Francesca Duraturo, Massimo Martinelli, Giovanni Battista Rossi, Annamaria Staiano, Paola Izzo and Marina De Rosa
Funding Agency and Grant Number	Funding Agency Grant Number Ministero Salute - Ricerca Oncologica - RECAM-2006-353005 PRIN 2007-prot. 2007EN8F7T-004 Convenzione CEINGE-Regione Campania. POR Campania FSE 2007-2013, Project CREME PRIN 2010-2011-prot. 2010K34C45_006
Corresponding Author	Marina De Rosa, PhD, Department of Molecular Medicine and Medical Biotechnology and CEINGE Biotecnologie Avanzate, University of Naples “Federico Ⅱ”, 80131 Naples, Italy. marina.derosa@unina.it
Key Words	Inflammatory bowel disease; Ulcerative colitis; Interleukin 10 receptors; Tumour necrosis factor α receptors; Beta catenin
Core Tip	We identified a novel point mutation within the interleukin-10 (IL10) receptor genes promoter (the -413G->T), associated with mRNA under-expression. We propose that this mutation has a synergistic effect with other variant alleles of IL10 receptor genes in very-early ulcerative colitis (UC) onset in this young child. β-catenin and tumour necrosis factor α receptors-I (TNFRI) protein were both over-expressed in peripheral blood cells of proband relatives, whereas TNFRII was over-expressed only in the proband. We suggest that β-catenin and TNFRI protein expression could represent molecular markers of sub-clinical disease in apparently healthy relatives of patients with early-onset UC.
Publish Date	2013-12-18 10:00
Citation	Galatola M, Miele E, Strisciuglio C, Paparo L, Rega D, Delrio P, Duraturo F, Martinelli M, Rossi GB, Staiano A, Izzo P, De Rosa M. Synergistic effect of interleukin-10-receptor variants in a case of early-onset ulcerative colitis. World J Gastroenterol 2013; 19(46): 8659-8670
URL	http://www.wjgnet.com/1007-9327/full/v19/i46/8659.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i46.8659

Full Article (PDF)	WJG-19-8659.pdf
Manuscript File	3593-Review.doc
Answering Reviewers	3593-Answering reviewers.pdf
Copyright License Agreement	3593-Copyright assignment.doc
Non-Native Speakers of English Editing Certificate	3593-Language certificate.pdf
Peer-review Report	3593-Peer reviewer(s).pdf
Scientific Editor Work List	3593-Scientific editor work list.doc