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Articles Published Processes
12/20/2017 2:49:19 AM | Browse: 1077 | Download: 1863
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Received |
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2017-09-06 03:04 |
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Peer-Review Started |
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2017-09-07 01:07 |
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To Make the First Decision |
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2017-10-11 01:00 |
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Return for Revision |
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2017-10-11 10:10 |
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Revised |
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2017-11-03 12:02 |
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Second Decision |
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2017-11-14 06:31 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-11-14 19:03 |
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Articles in Press |
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2017-11-14 19:03 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2017-11-19 15:24 |
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Typeset the Manuscript |
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2017-12-04 08:49 |
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Publish the Manuscript Online |
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2017-12-20 02:49 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Research & Experimental Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Effects of initiating time and dosage of Panax notoginseng on mucosal microvascular injury in experimental colitis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shi-Ying Wang, Ping Tao, Hong-Yi Hu, Jian-Ye Yuan, Lei Zhao, Bo-Yun Sun, Wan-Jun Zhang and Jiang Lin |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81373616 |
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| Corresponding Author |
Jiang Lin, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, No. 725, South Wanping Road, Shanghai 200032, China. linjiang@longhua.net |
| Key Words |
Microvascular injury; Panax notoginseng; Ulcerative colitis; Oxidative stress |
| Core Tip |
Panax notoginseng (PN) is a traditional Chinese medicine used to treat ulcerative colitis, but its mechanisms are unclear. In our study, we found that PN promoted repair of injuries of colonic mucosa and microvessels in rat colitis. PN decreased concentrations of vascular endothelial growth factor, interleukin (IL)-6 and tumor necrosis factor-α while it increased the concentrations of IL-4 and IL-10 in serum. It also decreased concentrations of myeloperoxidase and hypoxia-inducible factor-1α while it increased the concentration of superoxide dismutase in colon. So it is concluded that PN repairs mucosal and vascular injuries in rat colitis via attenuating inflammation and oxidative stress in the colonic mucosa. |
| Publish Date |
2017-12-20 02:49 |
| Citation |
Wang SY, Tao P, Hu HY, Yuan JY, Zhao L, Sun BY, Zhang WJ, Lin J. Effects of initiating time and dosage of Panax notoginseng on mucosal microvascular injury in experimental colitis. World J Gastroenterol 2017; 23(47): 8308-8320 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i47/8308.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i47.8308 |
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