Publication Name	World Journal of Hepatology
Manuscript ID	35965
Country	India

Received	2017-08-22 00:50
Peer-Review Started	2017-08-22 05:57
To Make the First Decision	2017-09-21 00:57
Return for Revision	2017-09-21 04:04
Revised	2017-10-23 04:02
Second Decision	2017-10-23 08:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-10-30 19:38
Articles in Press	2017-10-30 19:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-11-15 01:33
Publish the Manuscript Online	2017-11-16 01:53

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Role of pregnane X-receptor in regulating bacterial translocation in chronic liver diseases
Manuscript Source	Invited Manuscript
All Author List	Sundhar Mohandas and Balasubramaniyan Vairappan
ORCID	Author(s) ORCID Number Sundhar Mohandas http://orcid.org/orcid.org/0000-0002-7488-0528 Balasubramaniyan Vairappan http://orcid.org/0000-0003-1708-4864
Funding Agency and Grant Number	Funding Agency Grant Number Ramalingaswami Re-entry Fellowship BT/RLF/Re-entry/25/2012
Corresponding Author	Balasubramaniyan Vairappan, Assistant Professor, Liver Disease Research Lab, Department of Biochemistry, Jawaharlal Institute of PostgraduateMedical Education and Research, Dhanvantari Nagar, Pondicherry 605006, India. balamaniyan@gmail.com
Key Words	Pregnane X receptor; Bacterial translocation; Chronic liver disease; Intestinal permeability; Inflammation; Tight junctions
Core Tip	Translocation of bacteria at pathological levels is a major driving factor in the progression of chronic liver diseases (CLD). However, it remains to be known whether it is the CLD condition that triggers leaky gut, or if translocation of bacteria plays an etiological role in the pathogenesis of CLD. Dysregulation of homeostasis in the gut-liver axis is considered as a crucial element that underlies the pathogenesis of BT. The nuclear receptor, pregnane X receptor (PXR) is widely expressed in gut and liver axis and is implicated in maintenance of equilibrium in the gut-liver axis. This review will summarize the various studies that have highlighted the importance of PXR as the mechanistic linker molecule in the gut-liver axis and its role in regulating bacterial translocation in the pathogenesis of cirrhosis.
Publish Date	2017-11-16 01:53
Citation	Mohandas S, Vairappan B. Role of pregnane X-receptor in regulating bacterial translocation in chronic liver diseases. World J Hepatol 2017; 9(32): 1210-1226
URL	http://www.wjgnet.com/1948-5182/full/v9/i32/1210.htm
DOI	http://dx.doi.org/10.4254/wjh.v9.i32.1210

Full Article (PDF)	WJH-9-1210.pdf
Full Article (Word)	WJH-9-1210.doc
Manuscript File	35965-Review.docx
Answering Reviewers	35965-Answering reviewers.pdf
Audio Core Tip	35965-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	35965-Conflict-of-interest statement.pdf
Copyright License Agreement	35965-Copyright assignment.pdf
Peer-review Report	35965-Peer-review(s).pdf
Scientific Editor Work List	35965-Scientific editor work list.pdf