Publication Name	World Journal of Gastroenterology
Manuscript ID	35987
Country	China

Received	2017-08-25 00:26
Peer-Review Started	2017-08-25 03:27
To Make the First Decision	2017-10-11 00:50
Return for Revision	2017-10-11 04:16
Revised	2017-10-16 11:17
Second Decision	2017-10-26 04:23
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-10-27 04:01
Articles in Press	2017-10-27 04:01
Publication Fee Transferred	2017-10-31 05:27
Edit the Manuscript by Language Editor	2017-11-10 04:25
Typeset the Manuscript	2017-12-05 09:03
Publish the Manuscript Online	2017-12-12 08:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	miR-192-5p regulates lipid synthesis in non-alcoholic fatty liver disease through SCD-1 miR-192-5p regulates lipid synthesis through SCD-1
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Lin Liu, Hai-Xia Cao, Bao-Can Wang, Feng-Zhi Xin, Da Zhou, Rui-Nan Zhang, Rui-Xu Yang, Ze-Hua Zhao, Qin Pan and Jian-Gao Fan
ORCID	Author(s) ORCID Number Xiao-Lin Liu http://orcid.org/0000-0003-4560-7589 Hai-Xia Cao http://orcid.org/0000-0002-8265-9460 Bao-Can Wang http://orcid.org/0000-0002-6288-8100 Feng-Zhi Xin http://orcid.org/0000-0001-9674-0481 Da Zhou http://orcid.org/0000-0001-8838-1351 Rui-Nan Zhang http://orcid.org/0000-0001-9049-3010 Rui-Xu Yang http://orcid.org/0000-0001-9384-6408 Ze-Hua Zhao http://orcid.org/0000-0002-3708-8881 Qin Pan http://orcid.org/0000-0001-5855-4952 Jian-Gao Fan http://orcid.org/0000-0001-7443-5056
Funding Agency and Grant Number	Funding Agency Grant Number The National Key Research and Development Plan "Precision Medicine Research" No. 2017YFSF090203 The National Key Basic Research Project No. 2012CB517501 The National Natural Science Foundation of China No. 81470840 The National Natural Science Foundation of China No. 81600464
Corresponding Author	Jian-Gao Fan, PhD, Chief Doctor, Professor, Center for Fatty Liver, Department of Gastroenterology,, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai 200092, China. fanjiangao@xinhuamed.com.cn
Key Words	miR-192-5p; Stearoyl-CoA desaturase 1; High fat diet; Lipid synthesis; Non-alcoholic fatty liver disease
Core Tip	Hepatic miR-192-5p levels decreased in non-alcoholic steatohepatitis rat models fed with an high-fat diet and the decrease could be reversed after disease remission by liraglutide therapy. miR-192-5p showed a direct interaction with stearoyl-CoA desaturase 1 (SCD-1). miR-192-5p overexpression significantly alleviated lipid accumulation in Huh7 cells exposed to PA, and SCD-1 siRNA abrogated the lipid deposition aggravated by miR-192-5p inhibitors. Our study provides evidence that miR-192-5p participates in lipid synthesis in non-alcoholic fatty liver disease (NAFLD) through SCD-1 and provides new insight in that the overexpression of miR-192-5p may represent a promising treatment for NAFLD.
Publish Date	2017-12-12 08:34
Citation	Liu XL, Cao HX, Wang BC, Xin FZ, Zhang RN, Zhou D, Yang RY, Zhao ZH, Pan Q, Fan JG. MiR-192-5p regulates lipid synthesis in non-alcoholic fatty liver disease through SCD-1. World J Gastroenterol 2017; 23(46): 8140-8151
URL	http://www.wjgnet.com/1007-9327/full/v23/i46/8140.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i46.8140

Full Article (PDF)	WJG-23-8140.pdf
Full Article (Word)	WJG-23-8140.doc
Manuscript File	35987-Review.docx
Answering Reviewers	35987-Answering reviewers.pdf
Audio Core Tip	35987-Audio core tip.mp3
Biostatistics Review Certificate	35987-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	35987-Conflict-of-interest statement.pdf
Copyright License Agreement	35987-Copyright-License-Agreement-revision.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	35987-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	35987-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	35987-Institutional Review Board Statement.pdf
Non-Native Speakers of English Editing Certificate	35987-Language certificate.pdf
Peer-review Report	35987-Peer-review(s).pdf
Scientific Misconduct Check	35987-Scientific misconduct check.pdf
Scientific Editor Work List	35987-Scientific editor work list.pdf