Publication Name	World Journal of Cardiology
Manuscript ID	36002
Country	United States

Received	2017-08-25 01:45
Peer-Review Started	2017-08-25 06:23
To Make the First Decision	2017-09-25 00:46
Return for Revision	2017-09-25 08:13
Revised	2017-10-09 21:26
Second Decision	2017-11-06 08:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-11-10 18:39
Articles in Press	2017-11-10 18:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-12-19 08:27
Publish the Manuscript Online	2017-12-22 01:16

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Observational Study
Article Title	Endothelin-1 activation in pediatric patients undergoing surgical coarctation of the aorta repair
Manuscript Source	Unsolicited Manuscript
All Author List	Benjamin Steven Frank, Tracy T Urban, Suhong Tong, Courtney Cassidy, Max B Mitchell, Christopher S Nichols and Jesse A Davidson
ORCID	Author(s) ORCID Number Benjamin Steven Frank http://orcid.org/0000-0002-2227-6265 Tracy T Urban http://orcid.org/0000-0002-5064-9786 Suhong Tong http://orcid.org/0000-0002-0861-8775 Courtney Cassidy http://orcid.org/0000-0002-9560-6288 Max B Mitchell http://orcid.org/0000-0002-8350-0646 Christopher S Nichols http://orcid.org/0000-0002-2051-8136 Jesse A Davidson http://orcid.org/0000-0001-9193-9803
Funding Agency and Grant Number	Funding Agency Grant Number NIH/NCATS Colorado CTSA UL1 TR001082-04
Corresponding Author	Benjamin Steven Frank, MD, Academic Fellow, Division of Cardiology, Department of Pediatrics, University of Colorado Denver, 13123 E. 16th Ave, Box B100, Aurora, CO 80045, United States. benjamin.frank@childrenscolorado.org
Key Words	Biomarkers; Cardiac remodeling; Pediatric; Neonate; Left ventricular hypertrophy
Core Tip	Patients with coarctation of the aorta are at risk for a variety of short- and long-term complications after surgical repair. Endothelin-1 (ET-1) is a peptide hormone known to cause both cardiac myocyte hypertrophy and vasoconstriction that has been linked to late ventricular hypertrophy in this population. Peri-operative endothelin concentration in this population has not been previously defined. We demonstrate that neonates with coarctation of the aorta have high pre-operative ET-1 levels that decrease post-operatively. Older coarctation patients have more modest ET-1 activation that is unchanged post-operatively. These findings suggest two distinct patterns of ET-1 activation within this population.
Publish Date	2017-12-22 01:16
Citation	Frank BS, Urban TT, Tong S, Cassidy C, Mitchell MB, Nichols CS, Davidson JA. Endothelin-1 activation in pediatric patients undergoing surgical coarctation of the aorta repair. World J Cardiol 2017; 9(12): 822-829
URL	http://www.wjgnet.com/1949-8462/full/v9/i12/822.htm
DOI	http://dx.doi.org/10.4330/wjc.v9.i12.822

Full Article (PDF)	WJC-9-822.pdf
Full Article (Word)	WJC-9-822.doc
Manuscript File	36002-Review.docx
Answering Reviewers	36002-Answering reviewers.pdf
Audio Core Tip	36002-Audio core tip.mp3
Biostatistics Review Certificate	36002-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	36002-Conflict-of-interest statement.pdf
Copyright License Agreement	36002-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	36002-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	36002-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	36002-Institutional review board statement.pdf
Supplementary Material	36002-Supplementary-Material-revision.pdf
Peer-review Report	36002-Peer-review(s).pdf
Scientific Misconduct Check	36002-Scientific misconduct check.pdf
Scientific Editor Work List	36002-Scientific editor work list.pdf