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Articles Published Processes
12/22/2017 1:16:01 AM | Browse: 1349 | Download: 2635
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Received |
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2017-08-25 01:45 |
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Peer-Review Started |
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2017-08-25 06:23 |
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First Decision by Editorial Office Director |
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2017-09-22 23:43 |
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Return for Revision |
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2017-09-25 08:13 |
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Revised |
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2017-10-09 21:26 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2017-11-06 08:49 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2017-11-10 18:39 |
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Articles in Press |
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2017-11-10 18:39 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-12-19 08:27 |
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Publish the Manuscript Online |
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2017-12-22 01:16 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Observational Study |
| Article Title |
Endothelin-1 activation in pediatric patients undergoing surgical coarctation of the aorta repair
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Benjamin Steven Frank, Tracy T Urban, Suhong Tong, Courtney Cassidy, Max B Mitchell, Christopher S Nichols and Jesse A Davidson |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| NIH/NCATS Colorado CTSA |
UL1 TR001082-04 |
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| Corresponding Author |
Benjamin Steven Frank, MD, Academic Fellow, Division of Cardiology, Department of Pediatrics, University of Colorado Denver, 13123 E. 16th Ave, Box B100, Aurora, CO 80045, United States. benjamin.frank@childrenscolorado.org |
| Key Words |
Biomarkers; Cardiac remodeling; Pediatric; Neonate; Left ventricular hypertrophy |
| Core Tip |
Patients with coarctation of the aorta are at risk for a variety of short- and long-term complications after surgical repair. Endothelin-1 (ET-1) is a peptide hormone known to cause both cardiac myocyte hypertrophy and vasoconstriction that has been linked to late ventricular hypertrophy in this population. Peri-operative endothelin concentration in this population has not been previously defined. We demonstrate that neonates with coarctation of the aorta have high pre-operative ET-1 levels that decrease post-operatively. Older coarctation patients have more modest ET-1 activation that is unchanged post-operatively. These findings suggest two distinct patterns of ET-1 activation within this population. |
| Publish Date |
2017-12-22 01:16 |
| Citation |
Frank BS, Urban TT, Tong S, Cassidy C, Mitchell MB, Nichols CS, Davidson JA. Endothelin-1 activation in pediatric patients undergoing surgical coarctation of the aorta repair. World J Cardiol 2017; 9(12): 822-829 |
| URL |
http://www.wjgnet.com/1949-8462/full/v9/i12/822.htm |
| DOI |
http://dx.doi.org/10.4330/wjc.v9.i12.822 |
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