Publication Name	World Journal of Gastroenterology
Manuscript ID	36006
Country	China

Received	2017-09-01 00:14
Peer-Review Started	2017-09-03 07:49
To Make the First Decision	2017-09-20 00:06
Return for Revision	2017-09-21 08:42
Revised	2017-10-01 02:40
Second Decision	2017-11-01 07:16
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-11-01 21:09
Articles in Press	2017-11-01 21:09
Publication Fee Transferred	2017-11-06 07:21
Edit the Manuscript by Language Editor	2017-11-14 13:13
Typeset the Manuscript	2017-11-26 09:44
Publish the Manuscript Online	2017-12-04 08:09

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Mesenchymal stem cells rescue acute hepatic failure by polarizing M2 macrophages
Manuscript Source	Unsolicited Manuscript
All Author List	Yan-Wei Li, Chong Zhang, Qiu-Ju Sheng, Han Bai, Yang Ding and Xiao-Guang Dou
ORCID	Author(s) ORCID Number Yan-Wei Li http://orcid.org/0000-0001-6679-7460 Chong Zhang http://orcid.org/0000-0002-9434-786X Qiu-Ju Sheng http://orcid.org/0000-0001-7561-7396 Han Bai http://orcid.org/0000-0001-7228-8689 Yang Ding http://orcid.org/0000-0003-0836-7790 Xiao-Guang Dou http://orcid.org/0000-0002-5293-6009
Funding Agency and Grant Number	Funding Agency Grant Number Liaoning Provincial Science and Technology Key Project for Translational Medicine 2014225020 Outstanding Scientific Fund of Shengjing Hospital 201102 Liaoning Provincial Science and Technology Key Project for Translational Medicine 2016509
Corresponding Author	Xiao-Guang Dou, PhD, Chief Doctor, Department of Infectious Diseases, Shengjing Hospital of China Medical University, Huaxiang Street, Shenyang 110022, Liaoning Province, China. douxg@sj-hospital.org
Key Words	Acute hepatic failure; Mesenchymal stem cells; Macrophages; Polarization; Inflammation
Core Tip	M1 or M2 polarization governs the therapeutic effect of acute hepatic failure (AHF). Mesenchymal stem cells (MSCs) were transfused into rats with AHF induced by galactosamine. It was found that MSCs alleviated the survival rate and biochemical indicators by promoting hepatocyte regeneration. Immunohistochemistry, flow cytometry, and RT-PCR showed that M2 polarization contributes to the rescue of AHF by MSCs in the survival group after MSC transplantation. In addition, in the death group after MSC transplantation, the number of M1 macrophages increased significantly. Our findings suggest that M2 polarization contributes to the rescue of AHF by MSCs, which result in altered levels of anti-inflammatory and pro-inflammatory factors.
Publish Date	2017-12-04 08:09
Citation	Li YW, Zhang C, Sheng QJ, Bai H, Ding Y, Dou XG. Mesenchymal stem cells rescue acute hepatic failure by polarizing M2 macrophages. World J Gastroenterol 2017; 23(45): 7978-7988
URL	http://www.wjgnet.com/1007-9327/full/v23/i45/7978.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i45.7978

Full Article (PDF)	WJG-23-7978.pdf
Full Article (Word)	WJG-23-7978.doc
Manuscript File	36006-Review.docx
Answering Reviewers	36006-Answering reviewers.pdf
Audio Core Tip	36006-Audio-revision.amr
Biostatistics Review Certificate	36006-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	36006-Conflict-of-interest statement.pdf
Copyright License Agreement	36006-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	36006-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	36006-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	36006-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	36006-Language certificate.pdf
Supplementary Material	36006-Supplementary-Material-revision.PDF
Peer-review Report	36006-Peer-review(s).pdf
Scientific Misconduct Check	36006-Scientific misconduct check.pdf
Scientific Editor Work List	36006-Scientific editor work list.pdf