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Articles Published Processes
2/6/2018 3:22:41 AM | Browse: 1123 | Download: 2315
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Received |
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2017-09-14 07:12 |
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Peer-Review Started |
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2017-09-14 07:56 |
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First Decision by Editorial Office Director |
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2017-10-24 17:50 |
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Return for Revision |
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2017-10-26 02:03 |
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Revised |
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2017-11-06 13:56 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2017-11-27 09:00 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2017-11-27 20:29 |
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Articles in Press |
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2017-11-27 20:29 |
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Edit the Manuscript by Language Editor |
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2018-01-07 04:28 |
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Typeset the Manuscript |
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2018-01-28 06:12 |
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Publish the Manuscript Online |
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2018-02-06 03:22 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Inhibitory effects of patchouli alcohol on stress-induced diarrhea-predominant irritable bowel syndrome
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Tian-Ran Zhou, Jing-Jing Huang, Zi-Tong Huang, Hong-Ying Cao and Bo Tan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81573715 |
| Natural Science Foundation of Guangdong Province |
2015A030313348 |
| Science and Technology Program of Guangzhou |
201510010257 |
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| Corresponding Author |
Bo Tan, MD, PhD, Associate Professor, The Research Center for Integrative Medicine, School of Fundamental Medical Sciences, Guangzhou University of Chinese Medicine, 233 Waihuan Dong Rd, Guangzhou 510006, Guangdong Province, China. tannyhy@gzucm.edu.cn |
| Key Words |
Patchouli alcohol; Colonic longitudinal smooth muscles; Irritable bowel syndrome with predominant diarrhea; Enteric nervous system; Cholinergic nerves; Non-adrenergic non-cholinergic; Potassium channel |
| Core Tip |
We report our first results from an isolated colonic smooth muscle experiment in a chronic wrap-restraint stress-induced rat model of irritable bowel syndrome with predominant diarrhea (IBS-D). The model allowed the study of possible underlying mechanisms of IBS-D and inhibitory effect of patchouli alcohol (PA) on an isolated IBS-D rat colon. This study demonstrated for the first time the involvement of PA in both cholinergic and non-adrenergic non-cholinergic neurotransmitter regulation in the enteric nervous system (ENS) in vitro. PA acts as a neurotransmitter agent in ENS. All results suggest that PA is a new option to consider for IBS-D treatment. |
| Publish Date |
2018-02-06 03:22 |
| Citation |
Zhou TR, Huang JJ, Huang ZT, Cao HY, Tan B. Inhibitory effects of patchouli alcohol on stress-induced diarrhea-predominant irritable bowel syndrome. World J Gastroenterol 2018; 24(6): 693-705
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| URL |
http://www.wjgnet.com/1007-9327/full/v24/i6/693.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i6.693 |
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