Publication Name	World Journal of Neurology
Manuscript ID	3608
Country	United Kingdom

Received	2013-05-09 09:05
Peer-Review Started	2013-05-09 21:43
To Make the First Decision	2013-05-23 17:11
Return for Revision	2013-06-07 10:24
Revised
Second Decision	2013-10-16 09:11
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-10-16 10:29
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-12-19 18:58
Publish the Manuscript Online	2014-01-16 17:21

ISSN	2218-6212 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Neurosciences
Manuscript Type	Frontier
Article Title	Cannabinoids: Do they have the potential to treat the symptoms of multiple sclerosis?
Manuscript Source	Invited Manuscript
All Author List	Zubair Ahmed
Funding Agency and Grant Number	Funding Agency Grant Number University of Birmingham
Corresponding Author	Dr. Zubair Ahmed, Neurotrauma and Neurodegeneration Section, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Institute of Biomedical Research (West), Edgbaston, Birmingham B15 2TT, United Kingdom. z.ahmed.1@bham.ac.uk
Key Words	Multiple sclerosis; Axonal damage; Neurodegeneration; Neuroprotection
Core Tip	Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system and causes disability, neuropathic pain, spasticity and tremor in affected patients. Although illegal, users of cannabis report relief from pain and spasticity, probably due to the endogenous cannabinoid system that exists. cannabinoid receptor type-1 (CB1)-deficient mice accrue greater levels of neurodegeneration and poorly tolerate inflammatory and excitotoxic insults after immune attack in a model of MS, experimental allergic encephalomyelitis. Treatment of animals affected by experimental allergic uveitis (EAU) with CB1 agonists also provided significant neuroprotection from the consequences of EAU, suggesting that cannabinoids may slow down neurodegeneration in MS.
Publish Date	2014-01-16 17:21
Citation	Ahmed Z. Cannabinoids: Do they have the potential to treat the symptoms of multiple sclerosis? World J Neurol 2013; 3(4): 87-96
URL	http://www.wjgnet.com/2218-6212/full/v3/i4/87.htm
DOI	http://dx.doi.org/10.5316/wjn.v3.i4.87

Full Article (PDF)	WJN-3-87.pdf
Full Article (Word)	WJN-3-87.doc
Manuscript File	3608-Review.docx
Answering Reviewers	3608-Answering reviewers.pdf
Copyright License Agreement	3608-Copyright assignment.pdf
Peer-review Report	3608-Peer review(s).pdf
Scientific Editor Work List	3608-Scientific editor work list.doc