Publication Name	World Journal of Gastroenterology
Manuscript ID	36146
Country	Japan

Received	2017-09-13 10:37
Peer-Review Started	2017-09-14 03:25
To Make the First Decision	2017-10-11 00:52
Return for Revision	2017-10-12 03:00
Revised	2017-10-25 13:08
Second Decision	2017-11-07 08:28
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-11-07 18:24
Articles in Press	2017-11-07 18:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-11-27 00:51
Publish the Manuscript Online	2017-12-04 08:09

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Randomized Controlled Trial
Article Title	Efficacy of combination therapy with natriuretic and aquaretic drugs in cirrhotic ascites patients: A randomized study
Manuscript Source	Unsolicited Manuscript
All Author List	Haruki Uojima, Hisashi Hidaka, Tsuyoshi Nakayama, Ji Hyun Sung, Chikamasa Ichita, Shinnosuke Tokoro, Sakue Masuda, Akiko Sasaki, Kazuya Koizumi, Hideto Egashira and Makoto Kako
ORCID	Author(s) ORCID Number Haruki Uojima http://orcid.org/0000-0003-1719-1352 Hisashi Hidaka http://orcid.org/0000-0002-4151-5663 Tsuyoshi Nakayama http://orcid.org/0000-0001-7956-1975 Ji Hyun Sung http://orcid.org/0000-0002-3614-1740 Chikamasa Ichita http://orcid.org/0000-0001-9210-7371 Shinnosuke Tokoro http://orcid.org/0000-0001-9906-3754 Sakue Masuda http://orcid.org/0000-0002-8127-0154 Akiko Sasaki http://orcid.org/0000-0003-4219-554X Kazuya Koizumi http://orcid.org/0000-0002-3677-5030 Hideto Egashira http://orcid.org/0000-0002-6498-6230 Makoto Kako http://orcid.org/0000-0002-6447-8471
Funding Agency and Grant Number
Corresponding Author	Haruki Uojima, MD, Doctor, Doctor, Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0375, Japan. kiruha@kitasato-u.ac.jp
Key Words	Tolvaptan; Liver cirrhosis; Diuretic effect; Ascites; Hepatic edema
Core Tip	Whether a combination therapy with natriuretic and aquaretic drugs is more effective than conventional therapy with natriuretic drugs only for liver cirrhosis patients with ascites remains unclear. To clarify this, we compared the pharmacological effects of combination therapy with conventional therapy in cirrhotic ascites patients. Compared to a conventional therapy with only natriuretic drugs, a combination therapy with natriuretic and aquaretic drugs is more effective for patients with cirrhotic ascites.
Publish Date	2017-12-04 08:09
Citation	Uojima H, Hidaka H, Nakayama T, Sung JH, Ichita C, Tokoro S, Masuda S, Sasaki A, Koizumi K, Egashira H, Kako M. Efficacy of combination therapy with natriuretic and aquaretic drugs in cirrhotic ascites patients: A randomized study. World J Gastroenterol 2017; 23(45): 8062-8072
URL	http://www.wjgnet.com/1007-9327/full/v23/i45/8062.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i45.8062

Full Article (PDF)	WJG-23-8062.pdf
Full Article (Word)	WJG-23-8062.doc
Manuscript File	36146-Review.docx
Answering Reviewers	36146-Answering reviewers.pdf
Audio Core Tip	36146-Audio core tip.MP3
Biostatistics Review Certificate	36146-Biostatistics statement.pdf
Clinical Trial Registration Statement	36146-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	36146-Conflict-of-interest statement.pdf
Copyright License Agreement	36146-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	36146-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	36146-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	36146-Language certificate.pdf
Supplementary Material	36146-Supplementary material.pdf
Peer-review Report	36146-Peer-review(s).pdf
Scientific Editor Work List	36146-Scientific editor work list.pdf