Publication Name	World Journal of Gastroenterology
Manuscript ID	36189
Country	Poland

Received	2017-10-11 00:38
Peer-Review Started	2017-10-11 06:45
To Make the First Decision	2017-10-18 06:47
Return for Revision	2017-10-19 11:52
Revised	2017-11-03 17:48
Second Decision	2017-11-14 06:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-11-14 18:49
Articles in Press	2017-11-14 18:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-11-20 07:17
Publish the Manuscript Online	2017-11-27 02:36

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Intestinal parameters of oxidative imbalance in celiac adults with extraintestinal manifestations
Manuscript Source	Invited Manuscript
All Author List	Agnieszka Piatek-Guziewicz, Agata Ptak-Belowska, Magdalena Przybylska-Felus, Pawel Pasko, Pawel Zagrodzki, Thomas Brzozowski, Tomasz Hubert Mach and Malgorzata Zwolinska-Wcislo
ORCID	Author(s) ORCID Number Agnieszka Piatek-Guziewicz http://orcid.org/0000-0002-7936-0249 Agata Ptak-Belowska http://orcid.org/0000-0002-0294-5185 Magdalena Przybylska-Felus http://orcid.org/0000-0002-8730-9670 Pawel Pasko http://orcid.org/0000-0002-4821-4492 Pawel Zagrodzki http://orcid.org/0000-0002-5101-036X Thomas Brzozowski http://orcid.org/0000-0002-5805-0065 Tomasz Hubert Mach http://orcid.org/0000-0002-4963-2354 Malgorzata Zwolinska-Wcislo http://orcid.org/0000-0001-7868-1860
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Science and Higher Education K/ZDS/003811
Corresponding Author	Thomas Brzozowski, MD, PhD, Professor, Department of Physiology, Jagiellonian University Medical College, 16 Grzegorzecka Street, Cracow 31-531, Poland. mpbrzozo@cyf-kr.edu.pl
Key Words	Celiac disease; Oxidative stress; Superoxide dismutase; Heat-shock protein 70; Apoptosis; Hypoxia-inducible factor; Uric acid; Vitamin D; Tumor necrosis factor alpha
Core Tip	Oxidative stress has been implicated in gliadin toxicity. Additional measures aimed at reducing oxidative imbalance may prove to be effective supplementary therapy. We demonstrated increased duodenal expression of hypoxia-inducible factor 1 (HIF-1α), heat-shock protein 70 (HSP-70), and superoxide dismutase in adult celiac patients with extraintestinal manifestations as a defensive reaction to oxidative stress. Hence, HSP-70 and HIF-1α might be potential novel biomarkers of celiac disease (CD). Increased HSP-70 expression, both in treated and untreated celiac patients, suggests that oxidative stress as well as histopathological alterations in duodenal mucosa persist despite GFD. Our data confirm the increased serum levels of uric acid in patients with CD compared with controls as a result of oxidative stress.
Publish Date	2017-11-27 02:36
Citation	Piatek-Guziewicz A, Ptak-Belowska A, Przybylska-Felus M, Pasko P, Zagrodzki P, Brzozowski T, Mach T, Zwolinska-Wcislo M. Intestinal parameters of oxidative imbalance in celiac adults with extraintestinal manifestations. World J Gastroenterol 2017; 23(44): 7849-7862
URL	http://www.wjgnet. com/1007-9327/full/v23/i44/7849.htm
DOI	http://dx.doi. org/10.3748/wjg.v23.i44.7849

Full Article (PDF)	WJG-23-7849.pdf
Full Article (Word)	WJG-23-7849.doc
Manuscript File	36189-Review.doc
Answering Reviewers	36189-Answering reviewers.pdf
Audio Core Tip	36189-Audio core tip.mp3
Biostatistics Review Certificate	36189-Biostatistics statement.pdf
Clinical Trial Registration Statement	36189-Clinical Trial Registration Statement.pdf
Conflict-of-Interest Disclosure Form	36189-Conflict-of-interest statement.pdf
Copyright License Agreement	36189-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	36189-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	36189-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	36189-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	36189-Non-Native Speakers of English Editing Certificate.doc
Peer-review Report	36189-Peer-review(s).pdf
Scientific Misconduct Check	36189-Scientific misconduct check.pdf
Scientific Editor Work List	36189-Scientific editor work list.pdf