Publication Name	World Journal of Medical Genetics
Manuscript ID	36206
Country	United States

Received	2017-09-21 01:43
Peer-Review Started	2017-09-22 08:16
To Make the First Decision	2017-10-30 06:56
Return for Revision	2017-10-31 01:14
Revised	2017-11-18 22:05
Second Decision	2017-12-14 10:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-12-29 18:13
Articles in Press	2017-12-29 18:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-02-07 03:37
Publish the Manuscript Online	2018-02-08 07:54

ISSN	2220-3184 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Genetics & Heredity
Manuscript Type	Case Report
Article Title	Pedigree analysis supports a correlation between an AXIN2 variant and polyposis/colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Amrit Lamba, Parth Parekh, Chris T Dvorak and Jordan J Karlitz
ORCID	Author(s) ORCID Number Amrit Lamba http://orcid.org/0000-0001-7257-196X Parth Parekh http://orcid.org/0000-0003-4750-775X Chris T Dvorak http://orcid.org/0000-0002-6146-3952 Jordan J Karlitz http://orcid.org/0000-0001-5686-7365
Funding Agency and Grant Number
Corresponding Author	Parth Parekh, MD, Academic Fellow, Department of Gastroenterology, Carilion Clinic, 1906 Belleview Ave, Roanoke, VA 24016, United States. pjparekh@carilionclinic.org
Key Words	Colonic polyps; Colorectal cancer; Cancer genetics; Cancer syndrome; Cell signaling; Case report
Core Tip	Biochemical research, murine models, and 2 prior human families lend support to a genotypic-phenotypic correlation between alterations in the AXIN2 and polyposis/colorectal cancer. Our paper uses genetic testing and pedigree analysis to include a third family. This information would impact future genetic testing, the classification of identified variants, and screening in those with identified AXIN2 mutations and variants.
Publish Date	2018-02-08 07:54
Citation	Lamba A, Parekh P, Dvorak CT, Karlitz JJ. Pedigree analysis supports a correlation between an AXIN2 variant and polyposis/colorectal cancer. World J Med Genet 2018; 8(1): 1-4
URL	http://www.wjgnet.com/2220-3184/full/v8/i1/1.htm
DOI	http://dx.doi.org/10.5496/wjmg.v8.i1.1

Full Article (PDF)	WJMG-8-1.pdf
Full Article (Word)	WJMG-8-1.doc
Manuscript File	36206-Review.docx
Answering Reviewers	36206-Answering reviewers.pdf
Audio Core Tip	36206-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	36206-Conflict-of-interest statement.pdf
Copyright License Agreement	36206-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	36206-Informed consent statement.pdf
Peer-review Report	36206-Peer-review(s).pdf
Scientific Misconduct Check	36206-Scientific misconduct check.pdf
Scientific Editor Work List	36206-Scientific editor work list.pdf