Publication Name	World Journal of Gastroenterology
Manuscript ID	3632
Country	China

Received	2013-05-11 09:47
Peer-Review Started	2013-05-11 14:08
To Make the First Decision	2013-07-26 18:42
Return for Revision	2013-08-06 13:27
Revised	2013-09-04 23:31
Second Decision	2013-09-16 17:25
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-09-17 06:08
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-10-16 15:59
Publish the Manuscript Online	2013-11-13 08:37

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Abnormal DNA-PKcs and Ku 70/80 expression may promote malignant pathological processes in gastric carcinoma
Manuscript Source	Invited Manuscript
All Author List	Wei Li, Chuan Xie, Zhen Yang, Jiang Chen and Nong-Hua Lu
Funding Agency and Grant Number	Funding Agency Grant Number National natural science foundation of China 81270479
Corresponding Author	Nong-Hua Lu, MD, Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Yongzheng Road, Donghu District, Nanchang 330006, Jiangxi Province, China. lunonghua@ncu.edu.cn
Key Words	Helicobacter pylori; Catalytic subunit of the DNA-dependent protein kinase; Ku70/Ku80 heterodimer; Gastric carcinoma; Immunohistochemistry
Core Tip	This is the first study to clarify the two key promoters of the non-homologous end joining (NHEJ) pathway, DNA-dependent protein kinase (DNA-PKcs) and Ku 70/80, in human gastric carcinoma tissues. The present study found an upregulated expression of DNA-PKcs and Ku 70/80 in gastric cancer tissues compared with normal gastric mucosa, which suggests that there is an enhanced function of NHEJ in gastric carcinogenesis. As NHEJ is an error-prone and non-specific repair mechanism and can be induced before homologous recombination, its excessive activation is capable of regulating cell cycle arrest, cell apoptosis, chromosome recombination and genome instability.
Publish Date	2013-11-13 08:37
Citation	Li W, Xie C, Yang Z, Chen J, Lu NH. Abnormal DNA-PKcs and Ku 70/80 expression may promote malignant pathological processes in gastric carcinoma. World J Gastroenterol 2013; 19(40): 6894-6901
URL	http://www.wjgnet.com/1007-9327/full/v19/i40/6894.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i40.6894

Full Article (PDF)	WJG-19-6894.pdf
Manuscript File	3632-Review.doc
Answering Reviewers	3632-Answering reviewers.pdf
Copyright License Agreement	3632-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	3632-Language certificate.pdf
Peer-review Report	3632-Peer reviewer(s).pdf
Scientific Editor Work List	3632-Scientific editor work list.doc