Publication Name	World Journal of Gastroenterology
Manuscript ID	36362
Country	China

Received	2017-09-20 00:43
Peer-Review Started	2017-09-20 06:40
To Make the First Decision	2017-10-11 01:03
Return for Revision	2017-10-13 01:23
Revised	2017-10-24 09:55
Second Decision	2017-11-14 06:17
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-11-14 19:01
Articles in Press	2017-11-14 19:01
Publication Fee Transferred
Edit the Manuscript by Language Editor	2017-11-20 13:44
Typeset the Manuscript	2017-12-06 00:58
Publish the Manuscript Online	2017-12-12 08:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provide the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Integrative & Complementary Medicine
Manuscript Type	Basic Study
Article Title	Pharmacokinetics and pharmacodynamics of shengjiang decoction in rats with acute pancreatitis for protecting against multiple organ injuries
Manuscript Source	Unsolicited Manuscript
All Author List	Lv Zhu, Jun-Yi Li, Yu-Mei Zhang, Hong-Xin Kang, Huan Chen, Hang Su, Juan Li and Wen-Fu Tang
ORCID	Author(s) ORCID Number Lv Zhu http://orcid.org/0000-0002-4302-3339 Jun-Yi Li http://orcid.org/0000-0003-2599-2889 Yu-Mei Zhang http://orcid.org/0000-0001-9802-776X Hong-Xin Kang http://orcid.org/0000-0001-8212-0134 Huan Chen http://orcid.org/0000-0002-4763-6730 Hang Su http://orcid.org/0000-0003-2468-557X Juan Li http://orcid.org/0000-0002-5775-9355 Wen-Fu Tang http://orcid.org/0000-0001-9294-6634
Funding Agency and Grant Number	Funding Agency Grant Number the National Natural Science Foundation of China 81603519 the National Natural Science Foundation of China 81573857 the National Natural Science Foundation of China 81374042
Corresponding Author	Wen-Fu Tang, PhD, Professor, Sichuan Provincial Pancreatitis Center, Department of Integrative Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, Sichuan Province, China. tangwf@scu.edu.cn
Key Words	Shengjiang decoction; Pharmacokinetics; Pharmacodynamics; Pancreatic distribution; Acute pancreatitis
Core Tip	Shengjiang decoction (SJD) has been identified effectively in treating acute pancreatitis (AP) in vivo and in vitro tests. We report the metabolic processes of major components of SJD in vivo and the pharmacodynamic mechanism of SJD in relieving AP the first time. This study demonstrated that AP may have varying effects on the pharmacokinetics of the major SJD components in rats. Rhein and bisdemethoxycurcumin may be potential active components for the treatment of AP based on the hypothesis of tissue pharmacology of herbal recipe. SJD may attenuate AP by regulating inflammatory responses to protect against multiple organ injuries.
Publish Date	2017-12-12 08:34
Citation	Zhu L, Li JY, Zhang YM, Kang HX, Chen H, Su H, Li J, Tang WF. Pharmacokinetics and pharmacodynamics of Shengjiang decoction in rats with acute pancreatitis for protecting against multiple organ injury. World J Gastroenterol 2017; 23(46): 8169-8181
URL	http://www.wjgnet.com/1007-9327/full/v23/i46/8169.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i46.8169

Full Article (PDF)	WJG-23-8169.pdf
Full Article (Word)	WJG-23-8169.doc
Manuscript File	36362-Review.doc
Answering Reviewers	36362-Answering reviewers.pdf
Audio Core Tip	36362-Audio core tip.mp3
Biostatistics Review Certificate	36362-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	36362-Conflict-of-interest statement.pdf
Copyright License Agreement	36362-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	36362-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	36362-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	36362-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	36362-Language certificate.pdf
Supplementary Material	36362-Supplementary-Material-revision.jpg
Peer-review Report	36362-Peer-review(s).pdf
Scientific Misconduct Check	36362-Scientific misconduct check.pdf
Scientific Editor Work List	36362-Scientific editor work list.pdf