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12/20/2017 2:49:19 AM | Browse: 1079 | Download: 1245
Publication Name World Journal of Gastroenterology
Manuscript ID 36385
Country/Territory China
Received
2017-09-21 17:13
Peer-Review Started
2017-09-22 02:00
To Make the First Decision
2017-10-11 01:05
Return for Revision
2017-10-12 01:06
Revised
2017-10-20 08:59
Second Decision
2017-11-14 06:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-11-14 18:59
Articles in Press
2017-11-14 18:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
2017-11-20 13:40
Typeset the Manuscript
2017-12-06 06:39
Publish the Manuscript Online
2017-12-20 02:49
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Morin enhances hepatic Nrf2 expression in a liver fibrosis rat model
Manuscript Source Unsolicited Manuscript
All Author List Liang Sang, Xue-Mei Wang, Dong-Yang Xu, Li-Xuan Sang, Yan Han and Long-Yang Jiang
ORCID
Author(s) ORCID Number
Liang Sang http://orcid.org/0000-0002-9331-0985
Xue-Mei Wang http://orcid.org/0000-0002-4477-1865
Dong-Yang Xu http://orcid.org/0000-0001-8317-1718
Li-Xuan Sang http://orcid.org/0000-0002-4562-0022
Yan Han http://orcid.org/0000-0003-4133-6929
Long-Yang Jiang http://orcid.org/0000-0002-8409-7043
Funding Agency and Grant Number
Corresponding Author Xue-Mei Wang, MD, Doctor, Department of Ultrasound, The First Hospital of China Medical University, NO. 155 Nanjing North ST., Shenyang 110001, Liaoning, China. wangxuemei@cmu1h.com
Key Words Liver fibrosis; Rat; Morin; Nrf2
Core Tip We constructed a liver fibrosis rat model with carbon tetrachloride (CCl4). The Sprague-Dawley rats were randomly divided into four groups: control group, morin group, CCl4 group, and morin + CCl4 group. α-SMA, collagen Ⅰ, collagen Ⅲ, NF-E2-related factor 2 (Nrf2), heme oxygenase (HO-1), and quinone oxidoreductase 1 (NQO1) were analyzed by real-time PCR and Western blot methods using frozen liver specimens. We found that morin could reduce hepatic fibrosis by inducing the expression of Nrf2 and its downstream antioxidant factors in the CCl4-induced rat liver fibrosis model.
Publish Date 2017-12-20 02:49
Citation Sang L, Wang XM, Xu DY, Sang LX, Han Y, Jiang LY. Morin enhances hepatic Nrf2 expression in a liver fibrosis rat model. World J Gastroenterol 2017; 23(47): 8334-8344
URL http://www.wjgnet.com/1007-9327/full/v23/i47/8334.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i47.8334
Full Article (PDF) WJG-23-8334.pdf
Full Article (Word) WJG-23-8334.doc
Manuscript File 36385-Reiew.doc
Answering Reviewers 36385-Answering reviewers.pdf
Audio Core Tip 36385-Audio core tip.mp3
Biostatistics Review Certificate 36385-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 36385-Conflict-of-interest statement.pdf
Copyright License Agreement 36385-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 36385-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 36385-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 36385-Language certificate.pdf
Peer-review Report 36385-Peer-review(s).pdf
Scientific Misconduct Check 36385-Scientific misconduct check.pdf
Scientific Editor Work List 36385-Scientific editor work list.pdf