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1/7/2018 4:21:05 AM | Browse: 238 | Download: 228
Publication Name World Journal of Gastroenterology
Manuscript ID 36452
Country of Manuscript Source China
2017-09-29 01:08
Peer-Review Started
2017-09-30 00:45
To Make the First Decision
2017-10-18 07:24
Return for Revision
2017-10-20 03:44
2017-11-08 08:49
Second Decision
2017-11-21 10:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-11-21 18:43
Articles in Press
2017-11-21 18:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
2017-11-30 06:33
Typeset the Manuscript
2017-12-26 15:20
Publish the Manuscript Online
2018-01-07 04:21
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Case Control Study
Article Title Increased intestinal mucosal leptin levels in patients with diarrhea-predominant irritable bowel syndrome
Manuscript Source Unsolicited Manuscript
All Author List De-Rong Liu, Xiao-Juan Xu and Shu-Kun Yao
Author(s) ORCID Number
De-Rong Liu http://orcid.org/0000-0002-7052-5246
Xiao-Juan Xu http://orcid.org/0000-0001-6658-7279
Shu-Kun Yao http://orcid.org/0000-0002-8512-2589
Funding Agency and Grant Number
Funding Agency Grant Number
National Key Technology Support Program during “12th Five-Year Plan” Period of China 2014BAI08B02
Correspondence To Shu-Kun Yao, MD, PhD, Professor, Department of Gastroenterology, China-Japen Friendship Hospital, 2nd Yinghua East Road, Chaoyang District, Beijing 100029, China. shukunyao@126.com
Keywords Leptin; Irritable bowel syndrome; Mast cells; Diarrhea; Visceral hypersensitivity
Core Tip Leptin is an important cytokine that exerts significant biological effects on gastrointestinal function and immune system modulation. We found that diarrhea-predominant irritable bowel syndrome (IBS-D) patients had significantly increased psychological symptoms, visceral hypersensitivity, mucosal leptin expression, leptin mRNA expression, and mast cell activation rate. Additionally, leptin expression was positively correlated with anxiety, depression, and the mast cell activation rate, but negatively correlated with the defecation sensation threshold and maximum tolerance threshold during visceral sensitivity testing. Increased levels of mucosal leptin may interact with mast cells and the nervous system to contribute to the pathogenesis of IBS-D.
Publish Date 2018-01-07 04:21
Citation Liu DR, Xu XJ, Yao SK. Increased intestinal mucosal leptin levels in patients with diarrhea-predominant irritable bowel syndrome. World J Gastroenterol 2018; 24(1): 46-57
Url http://www.wjgnet.com/1007-9327/full/v24/i1/46.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i1.46
Full Article (PDF) WJG-24-46.pdf
Full Article (Word) WJG-24-46.doc
Manuscript File 36452-Review.doc
Answering Reviewers 36452-Answering reviewers.pdf
Audio Core Tip 36452-Audio core tip.m4a
Biostatistics Review Certificate 36452-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 36452-Conflict-of-interest statement.pdf
Copyright License Agreement 36452-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 36452-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 36452-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 36452-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 36452-Language certificate.pdf
Supplementary Material 36452-Supplementary-Material-revision.docx
Peer-review Report 36452-Peer-review(s).pdf
Scientific Misconduct Check 36452-Scientific misconduct check.pdf
Scientific Editor Work List 36452-Scientific editor work list.pdf