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Articles Published Processes
1/7/2018 4:21:05 AM | Browse: 1257 | Download: 2777
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Received |
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2017-09-29 01:08 |
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Peer-Review Started |
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2017-09-30 00:45 |
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To Make the First Decision |
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2017-10-18 07:24 |
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Return for Revision |
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2017-10-20 03:44 |
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Revised |
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2017-11-08 08:49 |
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Second Decision |
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2017-11-21 10:26 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-11-21 18:43 |
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Articles in Press |
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2017-11-21 18:43 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2017-11-30 06:33 |
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Typeset the Manuscript |
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2017-12-26 15:20 |
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Publish the Manuscript Online |
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2018-01-07 04:21 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Increased intestinal mucosal leptin levels in patients with diarrhea-predominant irritable bowel syndrome
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
De-Rong Liu, Xiao-Juan Xu and Shu-Kun Yao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Technology Support Program during “12th Five-Year Plan” Period of China |
2014BAI08B02 |
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| Corresponding Author |
Shu-Kun Yao, MD, PhD, Professor, Department of Gastroenterology, China-Japen Friendship Hospital, 2nd Yinghua East Road, Chaoyang District, Beijing 100029, China. shukunyao@126.com |
| Key Words |
Leptin; Irritable bowel syndrome; Mast cells; Diarrhea; Visceral hypersensitivity |
| Core Tip |
Leptin is an important cytokine that exerts significant biological effects on gastrointestinal function and immune system modulation. We found that diarrhea-predominant irritable bowel syndrome (IBS-D) patients had significantly increased psychological symptoms, visceral hypersensitivity, mucosal leptin expression, leptin mRNA expression, and mast cell activation rate. Additionally, leptin expression was positively correlated with anxiety, depression, and the mast cell activation rate, but negatively correlated with the defecation sensation threshold and maximum tolerance threshold during visceral sensitivity testing. Increased levels of mucosal leptin may interact with mast cells and the nervous system to contribute to the pathogenesis of IBS-D. |
| Publish Date |
2018-01-07 04:21 |
| Citation |
Liu DR, Xu XJ, Yao SK. Increased intestinal mucosal leptin levels in patients with diarrhea-predominant irritable bowel syndrome. World J Gastroenterol 2018; 24(1): 46-57 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i1/46.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i1.46 |
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