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Articles Published Processes
12/20/2017 2:49:19 AM | Browse: 1230 | Download: 1663
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Received |
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2017-10-03 17:03 |
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Peer-Review Started |
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2017-10-05 13:40 |
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To Make the First Decision |
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2017-10-18 06:49 |
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Return for Revision |
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2017-10-19 09:20 |
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Revised |
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2017-11-01 08:44 |
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Second Decision |
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2017-11-14 06:43 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-11-14 18:58 |
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Articles in Press |
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2017-11-14 18:58 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2017-11-25 19:57 |
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Typeset the Manuscript |
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2017-12-11 06:58 |
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Publish the Manuscript Online |
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2017-12-20 02:49 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Gene mutations in stool from gastric and colorectal neoplasia patients by next-generation sequencing
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Omar Youssef, Virinder Sarhadi, Homa Ehsan, Tom Böhling, Monika Carpelan-Holmström, Selja Koskensalo, Pauli Puolakkainen, Arto Kokkola and Sakari Knuutila |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Sigrid Jusélius Finnish Foundation |
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| Valtion tutkimusraha of Finland |
VTR TYH2016244 |
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| Corresponding Author |
Sakari Knuutila, PhD, Professor, Department of Pathology, Faculty of Medicine, University of Helsinki, Haartmaninkatu 4, Helsinki 00014, Finland. sakari.knuutila@helsinki.fi |
| Key Words |
Stool DNA; next-generation sequencing; Mutations; Gastric neoplasia; Colorectal neoplasia |
| Core Tip |
Next-generation sequencing (NGS) was successfully applied for detecting cancer gene mutations in stool DNA of patients with different gastrointestinal neoplasms. Using a gene panel, comprising up to 50 cancer genes, it was found that mutations not only could be detected in stool DNA from colorectal cancer patients but also in patients with stomach cancer and those with benign or premalignant lesions. No hotspot mutations were detected in healthy controls. Our results show that NGS could be useful in screening for neoplastic changes of the gastrointestinal tract. |
| Publish Date |
2017-12-20 02:49 |
| Citation |
Youssef O, Sarhadi V, Ehsan H, Böhling T, Carpelan-Holmström M, Koskensalo S, Puolakkainen P, Kokkola A, Knuutila S. Gene mutations in stool from gastric and colorectal neoplasia patients by next-generation sequencing. World J Gastroenterol 2017; 23(47): 8291-8299 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i47/8291.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i47.8291 |
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