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12/20/2017 2:49:19 AM | Browse: 1193 | Download: 1706
Publication Name World Journal of Gastroenterology
Manuscript ID 36534
Country/Territory Japan
Received
2017-10-04 19:58
Peer-Review Started
2017-10-05 14:31
To Make the First Decision
2017-10-25 01:06
Return for Revision
2017-10-25 08:53
Revised
2017-10-30 05:06
Second Decision
2017-11-14 06:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-11-14 18:55
Articles in Press
2017-11-14 18:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-12-07 00:58
Publish the Manuscript Online
2017-12-20 02:49
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Case Control Study
Article Title Rifaximin ameliorates hepatic encephalopathy and endotoxemia without affecting the gut microbiome diversity
Manuscript Source Unsolicited Manuscript
All Author List Kosuke Kaji, Hiroaki Takaya, Soichiro Saikawa, Masanori Furukawa, Shinya Sato, Hideto Kawaratani, Mitsuteru Kitade, Kei Moriya, Tadashi Namisaki, Takemi Akahane, Akira Mitoro and Hitoshi Yoshiji
ORCID
Author(s) ORCID Number
Kosuke Kaji http://orcid.org/orcid.org/0000-0002-1822-6759
Hiroaki Takaya http://orcid.org/orcid.org/0000-0002-4990-7573
Soichiro Saikawa http://orcid.org/0000-0002-3440-050X
Masanori Furukawa http://orcid.org/orcid.org/0000-0002-9317-9083
Shinya Sato http://orcid.org/orcid.org/0000-0003-3049-3443
Hideto Kawaratani http://orcid.org/0000-0002-4361-0592
Mitsuteru Kitade http://orcid.org/0000-0001-7592-7589
Kei Moriya http://orcid.org/0000-0002-2878-8296
Tadashi Namisaki http://orcid.org/orcid.org/0000-0002-3158-5318
Takemi Akahane http://orcid.org/orcid.org/0000-0002-6675-0475
Akira Mitoro http://orcid.org/orcid.org/0000-0002-6666-5633
Hitoshi Yoshiji http://orcid.org/orcid.org/0000-0002-5243-8544
Funding Agency and Grant Number
Corresponding Author Kosuke Kaji, MD, PhD, Assistant Professor, Doctor, Third Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara 6348522, Japan. kajik@naramed-u.ac.jp
Key Words Gut microbiome; Hepatic encephalopathy; Liver cirrhosis; Endotoxin; Rifaximin
Core Tip Hepatic encephalopathy (HE) is characterized by deficits in cognitive, psychiatric, and motor function and ranges in severity from minimal to overt HE and coma. Rifaximin is used for standard treatment of HE, targeting reduction of ammonia and gut bacterial translocation. This study demonstrates that rifaximin improves hyperammonemia and cognitive impairment with the linkage of decreased endotoxin activity in patients with decompensated cirrhosis. The diversity and major components of gut microbiome analyzed by 16S rRNA gene sequencing are not altered by treatment with rifaximin. This is the first report of systemic and local effects of rifaximin in Japanese patients.
Publish Date 2017-12-20 02:49
Citation Kaji K, Takaya H, Saikawa S, Furukawa M, Sato S, Kawaratani H, Kitade M, Moriya K, Namisaki T, Akahane T, Mitoro A, Yoshiji H. Rifaximin ameliorates hepatic encephalopathy and endotoxemia without affecting the gut microbiome diversity. World J Gastroenterol 2017; 23(47): 8355-8366
URL http://www.wjgnet.com/1007-9327/full/v23/i47/8355.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i47.8355
Full Article (PDF) WJG-23-8355.pdf
Full Article (Word) WJG-23-8355.doc
Manuscript File 36534-Review.docx
Answering Reviewers 36534-Answering reviewers.pdf
Audio Core Tip 36534-Audio core tip.mp3
Biostatistics Review Certificate 36534-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 36534-Conflict-of-interest statement.pdf
Copyright License Agreement 36534-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) 36534-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 36534-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 36534-Language certificate.pdf
Supplementary Material 36534-Supplementary material.pdf
Peer-review Report 36534-Peer-review(s).pdf
Scientific Misconduct Check 36534-Scientific misconduct check.pdf
Scientific Editor Work List 36534-Scientific editor work list.pdf