Publication Name	World Journal of Biological Chemistry
Manuscript ID	36538
Country	Spain

Received	2017-10-05 05:10
Peer-Review Started	2017-10-06 14:14
To Make the First Decision	2017-10-30 07:02
Return for Revision	2017-10-31 02:03
Revised	2017-11-10 07:55
Second Decision	2017-11-14 11:09
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-11-20 07:16
Articles in Press	2017-11-20 07:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-11-23 00:19
Publish the Manuscript Online	2017-11-24 00:55

ISSN	1949-8454 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Biochemistry & Molecular Biology
Manuscript Type	Minireviews
Article Title	PDRG1 at the interface between intermediary metabolism and oncogenesis
Manuscript Source	Unsolicited Manuscript
All Author List	María Ángeles Pajares
ORCID	Author(s) ORCID Number María Ángeles Pajares http://orcid.org/0000-0002-4714-9051
Funding Agency and Grant Number
Corresponding Author	María Ángeles Pajares, PhD, Senior Scientist, Department of Chemical and Physical Biology, Centro de Investigaciones Biologicas (CSIC), Ramiro de Maeztu 9, Madrid 28040, Spain. mapajares@cib.csic.es
Key Words	Epigenetic modifications; Glutathione; Methylation; Oncogenes; Intermediary metabolism; p53 and DNA damage-regulated gene 1; Protein complexes; R2TP/prefoldin complex; S-adenosylmethionine synthesis; Redox stress
Core Tip	PDRG1 is an understudied protein of the R2TP/prefoldin-like complex that has been found as part of different multiprotein complexes. Increased PDRG1 expression levels have been associated with several types of tumors that concomitantly show global DNA hypomethylation. More recently, this protein has been uncovered as an interaction target for methionine adenosyltransferase catalytic subunits MATa1 and MATa2. Through this interaction, PDRG1 downregulates nuclear S-adenosylmethionine synthesis, hence impacting epigenetic methylations.
Publish Date	2017-11-24 00:55
Citation	Pajares MÁ. PDRG1 at the interface between intermediary metabolism and oncogenesis. World J Biol Chem 2017; 8(4): 175-186
URL	http://www.wjgnet.com/1949-8454/full/v8/i4/175.htm
DOI	http://dx.doi.org/10.4331/wjbc.v8.i4.175

Full Article (PDF)	WJBC-8-175.pdf
Full Article (Word)	WJBC-8-175.doc
Manuscript File	36538-Review.docx
Answering Reviewers	36538-Answering reviewers.pdf
Audio Core Tip	36538-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	36538-Conflict-of-interest statement.pdf
Copyright License Agreement	36538-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	36538-Language certificate.pdf
Peer-review Report	36538-Peer-review(s).pdf
Scientific Misconduct Check	36538-Scientific misconduct check.pdf
Scientific Editor Work List	36538-Scientific editor work list.pdf